|Centuries:||5th century – 6th century – 7th century|
|Decades:||510s 520s 530s – 540s – 550s 560s 570s|
|Years:||540 541 542 – 543 – 544 545 546|
|543 by topic|
|State leaders – Sovereign states|
|Birth and death categories|
|Births – Deaths|
|Establishment and disestablishment categories|
|Establishments – Disestablishments|
|Ab urbe condita||1296|
|Bahá'í calendar||-1301 – -1300|
|English Regnal year||N/A|
|Chinese calendar||壬戌年 (Water Dog)
3239 or 3179
— to —
癸亥年 (Water Pig)
3240 or 3180
|- Vikram Samvat||599–600|
|- Shaka Samvat||465–466|
|- Kali Yuga||3644–3645|
|Igbo calendar||-457 – -456|
|Iranian calendar||79 BP – 78 BP|
|Islamic calendar||81 BH – 80 BH|
|Minguo calendar||1369 before ROC
|Thai solar calendar||1086|
|Wikimedia Commons has media related to 543.|
Year 543 (DXLIII) was a common year starting on Thursday (link will display the full calendar) of the Julian calendar. The denomination 543 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.
- Spring – Siege of Naples: The Byzantine garrison (1,000 men) in Naples surrenders to the Ostrogoths. Pressed by famine and demoralized by the failure of two relief efforts. The defenders are well treated by king Totila, and the garrison is allowed safe departure, but the city walls are partly razed.
- The fortress city of Old Dongola (modern Sudan) along the Nile River becomes the capital of Makuria. Several churches are built, including the "Old Church" (approximate date).
- Summer – King Khosrau I invades again Syria and turns south towards Edessa to besiege the fortress city.
- The Hephthalites threaten the Persian Empire from the East. They extend their domain in Central Asia (approximate date).
- King Pulakesi I establishes the Chalukya Dynasty (India). He extends his kingdom by conquering Vakataka and the west coast of Karnataka giving him access to the valuable Arabian Sea trade routes.
- Brunhilda, queen of Austrasia (approximate date)
- Columbanus, Irish missionary (d. 615)
- Jing Di, emperor of the Liang Dynasty (d. 558)
- Wu Di, emperor of Northern Zhou (d. 578)
- Bury (1923), Vol. II, Chapter XIX, p. 231-233
- Bauer, Susan Wise (2010). The History of the Medieval World: "From the Conversion of Constantine to the First Crusade", p. 231. ISBN 978-0-393-05975-5