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Alkaline ceramidase 1
Symbols ACER1 ; ALKCDase1; ASAH3
External IDs OMIM613491 MGI2181962 HomoloGene15853 IUPHAR: 2468 GeneCards: ACER1 Gene
EC number
Species Human Mouse
Entrez 125981 171168
Ensembl ENSG00000167769 ENSMUSG00000045019
UniProt Q8TDN7 Q8R4X1
RefSeq (mRNA) NM_133492 NM_175731
RefSeq (protein) NP_597999 NP_783858
Location (UCSC) Chr 19:
6.31 – 6.33 Mb
Chr 17:
56.95 – 56.98 Mb
PubMed search [1] [2]

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.[1]


ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P).[1]


  1. ^ a b Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM (August 2003). "Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides". J. Biol. Chem. 278 (33): 31184–91. doi:10.1074/jbc.M303875200. PMID 12783875. 

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