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Alkaline ceramidase 2
Symbols ACER2 ; ALKCDase2; ASAH3L
External IDs OMIM613492 MGI1920932 HomoloGene14986 IUPHAR: 2469 GeneCards: ACER2 Gene
EC number
Species Human Mouse
Entrez 340485 230379
Ensembl ENSG00000177076 ENSMUSG00000038007
UniProt Q5QJU3 Q8VD53
RefSeq (mRNA) NM_001010887 NM_139306
RefSeq (protein) NP_001010887 NP_647467
Location (UCSC) Chr 9:
19.41 – 19.45 Mb
Chr 4:
86.87 – 86.93 Mb
PubMed search [1] [2]

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.[1]


The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.[2]


  1. ^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555. 
  2. ^ Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656–66. doi:10.1096/fj.08-115634. PMC 2630785. PMID 18945876. 

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