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Alkaline ceramidase 3
Symbols ACER3 ; APHC; PHCA
External IDs MGI1913440 HomoloGene5410 IUPHAR: 2470 GeneCards: ACER3 Gene
EC number
Species Human Mouse
Entrez 55331 66190
Ensembl ENSG00000078124 ENSMUSG00000030760
UniProt Q9NUN7 Q9D099
RefSeq (mRNA) NM_018367 NM_025408
RefSeq (protein) NP_060837 NP_079684
Location (UCSC) Chr 11:
76.57 – 76.74 Mb
Chr 7:
98.21 – 98.32 Mb
PubMed search [1] [2]

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene.[1][2]


  1. ^ Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001). "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. Chem. 276 (28): 26577–88. doi:10.1074/jbc.M102818200. PMID 11356846. 
  2. ^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555. 

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