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UDP-glucose ceramide glucosyltransferase
Symbols UGCG ; GCS; GLCT1
External IDs OMIM602874 MGI1332243 HomoloGene37763 IUPHAR: 2528 ChEMBL: 2063 GeneCards: UGCG Gene
EC number
RNA expression pattern
PBB GE UGCG 204881 s at tn.png
PBB GE UGCG 221765 at tn.png
More reference expression data
Species Human Mouse
Entrez 7357 22234
Ensembl ENSG00000148154 ENSMUSG00000028381
UniProt Q16739 O88693
RefSeq (mRNA) NM_003358 NM_011673
RefSeq (protein) NP_003349 NP_035803
Location (UCSC) Chr 9:
114.66 – 114.7 Mb
Chr 4:
59.19 – 59.22 Mb
PubMed search [1] [2]

Ceramide glucosyltransferase is an enzyme that in humans is encoded by the UGCG gene.[1][2][3]

Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.[3]


UGCG has been shown to interact with RTN1 .[4]


  1. ^ Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (Jul 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proc Natl Acad Sci U S A 93 (10): 4638–43. Bibcode:1996PNAS...93.4638I. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456. 
  2. ^ Ichikawa S, Ozawa K, Hirabayashi Y (Jun 1998). "Assignment of a UDP-glucose:ceramide glucosyltransferase gene (UGCG) to human chromosome band 9q31 by in situ hybridization". Cytogenet Cell Genet 79 (3–4): 233–4. doi:10.1159/000134731. PMID 9605861. 
  3. ^ a b "Entrez Gene: UGCG UDP-glucose ceramide glucosyltransferase". 
  4. ^ Di Sano, Federica; Fazi Barbara; Citro Gennaro; Lovat Penny E; Cesareni Gianni; Piacentini Mauro (Jul 2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. (United States) 63 (14): 3860–5. ISSN 0008-5472. PMID 12873973. 

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