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Acyl-CoA thioesterase 8
External IDs OMIM608123 MGI2158201 HomoloGene3991 GeneCards: ACOT8 Gene
EC number
RNA expression pattern
PBB GE ACOT8 204212 at tn.png
More reference expression data
Species Human Mouse
Entrez 10005 170789
Ensembl ENSG00000101473 ENSMUSG00000017307
UniProt O14734 P58137
RefSeq (mRNA) NM_005469 NM_133240
RefSeq (protein) NP_005460 NP_573503
Location (UCSC) Chr 20:
44.47 – 44.49 Mb
Chr 2:
164.79 – 164.8 Mb
PubMed search [1] [2]

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.[1][2][3][4][5]

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene.[5]


  1. ^ Jones JM, Nau K, Geraghty MT, Erdmann R, Gould SJ (Apr 1999). "Identification of peroxisomal acyl-CoA thioesterases in yeast and humans". J Biol Chem 274 (14): 9216–23. doi:10.1074/jbc.274.14.9216. PMID 10092594. 
  2. ^ Liu LX, Margottin F, Le Gall S, Schwartz O, Selig L, Benarous R, Benichou S (Jul 1997). "Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation". J Biol Chem 272 (21): 13779–85. doi:10.1074/jbc.272.21.13779. PMID 9153233. 
  3. ^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133. 
  4. ^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. 
  5. ^ a b "Entrez Gene: ACOT8 acyl-CoA thioesterase 8". 

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