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Palmitoyl-protein thioesterase 2
PDB 1pja EBI.jpg
PDB rendering based on 1pja.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PPT2 ; C6orf8; G14; PPT-2
External IDs OMIM603298 MGI1860075 HomoloGene10448 GeneCards: PPT2 Gene
EC number
Species Human Mouse
Entrez 9374 54397
Ensembl ENSG00000168452 ENSMUSG00000015474
UniProt Q9UMR5 O35448
RefSeq (mRNA) NM_001204103 NM_019441
RefSeq (protein) NP_001191032 NP_062314
Location (UCSC) Chr 6:
32.12 – 32.13 Mb
Chr 17:
34.62 – 34.63 Mb
PubMed search [1] [2]

Lysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase G14, is an enzyme that in humans is encoded by the PPT2 gene.[1][2][3]


This gene encodes a member of the palmitoyl protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins.[1]


  1. ^ a b "Entrez Gene: palmitoyl-protein thioesterase 2". 
  2. ^ Soyombo AA, Hofmann SL (October 1997). "Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity". J. Biol. Chem. 272 (43): 27456–63. doi:10.1074/jbc.272.43.27456. PMID 9341199. 
  3. ^ Soyombo AA, Yi W, Hofmann SL (March 1999). "Structure of the human palmitoyl-protein thioesterase-2 gene (PPT2) in the major histocompatibility complex on chromosome 6p21.3". Genomics 56 (2): 208–16. doi:10.1006/geno.1998.5703. PMID 10051407. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.