|Scanning electron micrograph of Actinomyces israelii.|
|Class:||Actinobacteria Stackebrandt et al. 1997|
|Subclasses & Orders|
Actinobacteria are a group of Gram-positive bacteria. They were all believed to have high guanine and cytosine content in their DNA. However, recently it has been shown that several freshwater Actinobacteria actually have low G+C content.  The G+C content of freshwater Actinobacteria can be as low as 42%. In view of this, use of the epithet high G+C Gram positive organisms to refer to Actinobacteria needs to be discontinued. They can be terrestrial or aquatic. Although understood primarily as soil bacteria, they might be more abundant in freshwaters. Actinobacteria is one of the dominant bacterial phyla and contains one of the largest of bacterial genera, Streptomyces. Analysis of glutamine synthetase sequence has been suggested for phylogenetic analysis of Actinobacteria.
Although some of the largest and most complex bacterial cells belong to the Actinobacteria, the group of marine Actinomarinales has been described as possessing the smallest free-living prokaryotic cells.
Microbial diversity is a vast frontier and potential goldmine for the biotechnology industry because it offers countless new genes and biochemical pathways to probe for enzymes, antibiotics and other useful molecules The structure of the soil represents a good indicator for the biologic activity, as soil aggregates define the most important microhabitats for microorganisms. The soil should have enough pores, filled with gases, in order to allow the gas exchange with the atmosphere, reducing thus the risk of formation of the anaerobic area. Within the aerobiosis, the activity of microorganisms is much more intense, and the mineralization processes take place in optimal conditions.
Most Actinobacteria of medical or economic significance are in subclass Actinobacteridae, order Actinomycetales. While many of these cause disease in humans, Streptomyces is notable as a source of antibiotics.
Of those Actinobacteria not in Actinomycetales, Gardnerella is one of the most researched. Classification of Gardnerella is controversial, and MeSH catalogues it as both a gram-positive and gram-negative organism.
Actinomycetes have been recognized as the potential producers of metabolites such as antibiotics, growth promoting substances for plants and animals, immunomodifiers, enzyme inhibitors and many other compounds of use to man.antibiotics including many of those important in medicine, such as aminoglycosides, anthracyclines, chloramphenicol, macrolide, tetracyclines etc.
Actinomycetes are prokaryotes which have a hyphal morphology. Most of the actinomycetes are unparalleled sources of bio-active metabolites including antibiotics, plant growth factors and other substances 
Actinomycetes are known to produce bioactive substances, especially antibiotics that are effective against phytopathogenic fungi 
Among all the known microbes, members of the actinomycetes genus especially Streptomyces sp. have been recognised as prolific producer of useful bioactive metabolite with broad spectrum of activities which has antibacterial, antifungal, antibiotic, antiphrastic antitumor, antiviral,insecticide, herbicide, immunomodulators, antithrombatic agents 
Streptomyces and other actinomycetes are major contributes to biological buffering of soils and have role in organic matter decomposition conductive to crop production
The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)  and National Center for Biotechnology Information (NCBI) and the phylogeny is based on 16S rRNA-based LTP release 106 by The All-Species Living Tree Project 
♪ Prokaryotes where no pure (axenic) cultures are isolated or available, i. e. not cultivated or can not be sustained in culture for more than a few serial passages
♠ Strains found at the National Center for Biotechnology Information (NCBI) but not listed in the List of Prokaryotic names with Standing in Nomenclature (LSPN)
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