Cilazapril

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Cilazapril
Kekulé, stereo, skeletal formula of cilazapril ((1S,9S)-9-[(2S)-2-yl]amin,-1-carbox)
Identifiers
CAS number 88768-40-5 N
PubChem 56330, 40467985 (1R,9S)-(2S)-butylamino isomer
ChemSpider 50831 N
UNII 8Q9454114Q N
DrugBank DB01340
KEGG D07699 YesY
ChEMBL CHEMBL515606 N
ATC code C09AA08
Jmol-3D images Image 1
Properties
Molecular formula C22H31N3O5
Molar mass 417.50 g mol−1
log P 2.212
Acidity (pKa) 2.285
Basicity (pKb) 11.712
Pharmacology
Routes of
administration
Oral
Legal status

POM(UK)

Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Cilazapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure.[1][2] It is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these are available in the United States as of May 2010.[3]

Of the eight possible stereoisomers, only the all-S form is medically viable.[citation needed]

References[edit]

  1. ^ Szucs, T. (1991). "Cilazapril. A review". Drugs. 41 Suppl 1: 18–24. PMID 1712267.  edit
  2. ^ Jasek, W, ed. (2007). Austria-Codex (in German) (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4. 
  3. ^ Drugs.com: Cilazapril
  • Cilazapril monograph. Lexi-Comp Online, Lexi-Drugs Online, Lexi-Comp Inc. Hudson, OH. Available at: [1]. Accessed October 5, 2008.