Cryoprecipitate, also called "Cryoprecipitated Antihaemophilic Factor", "Cryoprecipitated AHF", and "cryo" for short, is a frozen blood product prepared from plasma. To acquire cryoprecipitate, thawed fresh frozen plasma should be centrifuged and the precipitate should be collected.
It is often transfused as a four to six unit pool instead of as a single product. Many uses of the product have been replaced by factor concentrates, but it is still routinely stocked by many hospital blood banks.
Like fresh frozen plasma, compatibility testing is not strictly necessary, but cryo is given as ABO compatible when possible. (Compatibility is reversed for plasma products: AB type is the universal plasma donor and O type is the universal plasma recipient.)
US standards require manufacturers to test at least four units each month, and the products must have an average of 150 mg or more of fibrinogen and 80 IU of factor VIII. Individual products may actually have less than these amounts as long as the average remains above these minimums. Typical values for a unit are substantially higher, and aside from infants it is rare to transfuse just one unit.
Indications for giving cryoprecipitate include:
- Haemophilia - Used for emergency back up when factor concentrates are not available.
- von Willebrands's disease - Not currently recommended unless last reserve. ddAVP is first line, followed by factor concentrates.
- Hypofibrinogenaemia (low fibrinogen levels), as can occur with massive transfusions
- Bleeding from excessive anticoagulation - Fresh frozen plasma contains most of the coagulation factors and is a much better choice when anticoagulation has to be reversed quickly.
- Massive haemorrhage - RBCs and volume expanders are preferred therapies.
- Disseminated intravascular coagulation
- "Circular of Information For the Use of Human Blood and Blood Components" (PDF). Archived from the original on 2008-02-27. Retrieved 2008-02-28.
- Erber WN, Perry DJ (2006). "Plasma and plasma products in the treatment of massive haemorrhage". Best Pract Res Clin Haematol 19 (1): 97–112. doi:10.1016/j.beha.2005.01.026. PMID 16377544.