Ecthyma gangrenosum
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| Ecthyma gangrenosum | |
|---|---|
| Classification and external resources | |
| DiseasesDB | 29391 |
| eMedicine | derm/539 |
Ecthyma gangrenosum is an infection of the skin typically caused by Pseudomonas aeruginosa. It presents as a round or oval lesion, 1 cm to 15 cm in diameter, with a halo of erythema. A necrotic center is usually present with a surrounding erythematous edge, representing where the organism invaded blood vessels and caused infarctions. These ulceritic lesions are single or multiple and heal with scar formation. The mechanism of tissue destruction is Pseudomonas exotoxin A, a toxin similar to Corynebacterium diphtheriae toxin that causes inactivation of elongation factor 2, although sepsis resulting from other gram negative bacteria can also cause this condition.
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