Farnesyl pyrophosphate
 |
This article does not cite any references or sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2009) |
| Farnesyl pyrophosphate | |
|---|---|
 |
|
 |
|
| Identifiers | |
| CAS number | 13058-04-3  |
| PubChem | 706 |
| MeSH | farnesyl+pyrophosphate |
| Properties | |
| Molecular formula | C15H28O7P2 |
| Molar mass | 382.326 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
|
| Infobox references | |
Farnesyl pyrophosphate (FPP), also known as farnesyl diphosphate (FDP), is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes, terpenoids, and sterols.
It is the immediate precursor of squalene (via the enzyme squalene synthase), dehydrodolichol diphosphate (a precursor of dolichol), and geranylgeranyl pyrophosphate (GGPP).
[edit] Biosynthesis
Farnesyl pyrophosphate synthase (a prenyl transferase) catalyzes sequential condensation reactions of dimethylallyl pyrophosphate with 2 units of 3-isopentenyl pyrophosphate to form farnesyl pyrophosphate, as is shown in the following two steps:
- Dimethylallyl pyrophosphate reacts with 3-isopentenyl pyrophosphate to form geranyl pyrophosphate:
- Geranyl pyrophosphate then reacts with another molecule of 3-isopentenyl pyrophosphate to form farnesyl pyrophosphate
[edit] Regulation
The above reactions are inhibited by bisphosphonates (used for osteoporosis).
[edit] Related compounds
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
