G cell

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G cell
Control-of-stomach-acid-sec.png
Control of stomach acid
Latin endocrinocytus G
Code TH H3.04.02.0.00031
Anatomical terminology

In anatomy, the G cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells.

G cells are found deep within the pyloric glands of the stomach antrum, and occasionally in the pancreas[1] and duodenum.

The vagus nerve innervates the G cells.

Gastrin-releasing peptide is released by the post-ganglionic fibers of the vagus nerve onto G cells during parasympathetic stimulation. The peptide hormone bombesin also stimulates gastrin from G cells.

Gastrin-releasing peptide, as well as the presence of amino acids in the stomach, stimulates the of gastrin from the G cells. Gastrin stimulates enterochromaffin-like cells to secrete histamine.[2]

Gastrin also targets parietal cells by increasing the amount of histamine and the direct stimulation by gastrin, causing the parietal cells to increase HCl secretion in the stomach.

Histomorphology[edit]

Micrograph of the gastric antrum showing abundant fried egg-like G cells. H&E stain.

G cells have a distinctive microscopic appearance that allows one to separate them from other cells in the gastric antrum; their nuclei are centrally located in the cell. They are found in the middle portion of the gastric glands

References[edit]

  1. ^ "G cell", Medcyclopaedia (GE), archived from the original on 2012-02-05 
  2. ^ Guyton, Arthur C.; John E. Hall (2006). Textbook of Medical Physiology (11 ed.). Philadelphia: Elsevier Saunders. p. 797. ISBN 0-7216-0240-1. 

External links[edit]