Mounds from the 5th to 10th centuries show that the surrounding lands have been inhabited for a long time. Kunigiškės, Kauno Vokė and Salos-Afindevičiai villages were there, modern Grigiškės settlement was founded only in the 20th century.
The name was given by Grzegorz Kurec an industrialist of Belarusian-descent, who built a paper and cardboard factory and a water power plant with a unique Grigiškės water aqueduct.
In the aftermath of the war, factory was expanded, many new workplaces were created and returning Belarusian workers from Siberia, whom were prohibited to live in Vilnius, settled here. In the Soviet era, Grigiškės factory also manufactured wood fibre panels.
On 15 May 1958, Grigiškės became an urban-type settlement and the first Lithuanian schools were established. In 1968, a library was built. On 10 December 1996, by the decree of the Lithuanian president, Grigiškės coat-of-arms was finally validated. Since 19 March 2000 (official since 21 December 1999), Grigiškės has been part of Vilnius city municipality.