Blair was impressive in his debut. He had 16 disposals (7 kicks and 9 handballs), took 2 marks and had 5 tackles in an 83 point win for Collingwood. The week after against Port Adelaide he continued to impress by kicking 2 goals. In Round 20 against Essendon, he was one of the best players in Collingwood's 98 point win. His 27 disposals and 2 goals was rewarded with one vote in the Brownlow Medal.
Blair played in the drawn 2010 AFL Grand Final and was a member of Collingwood's Premiership side a week later in the replay. At 20 years of age Blair was the second-youngest member of Collingwood's 2010 Premiership team after 19-year old Steele Sidebottom.
In Round 3 of 2011, Blair kicked a career-high 5 goals against Carlton. In Round 20 that year he kicked four goals against Port Adelaide.
He is the nephew of Morningside premiership coach and former VFL player John Blair. Blair's grandfather John O'Mahony played for Hawthorn between 1951 and 1960.