The name comes from ka pā lama in the Hawaiian language which means "the enclosure of lama wood". "Lama" was the Hawaiian name for endemic ebony trees of genus Diospyros that were used in religious ceremonies.
Traditional land divisions (ahupuaʻa) in ancient Hawaii were agricultural units that ran from the seashore to mountains. The shoreline areas of Kapālama were later developed into part of Honolulu harbor. The upland areas of Kapālama developed into ‘Ālewa Heights, and the main campus of Kamehameha Schools. Other educational institutions range from Honolulu Community College to the Kapālama Elementary school. Palama Street at Coordinates: , and Kapālama Avenue at , are named for the neighborhood. The Kapālama Stream starts at and then runs into the Kapālama canal and basin. To the northwest is the neighborhood of Kalihi, and to the southeast downtown Honolulu.
The Kapalama Military Reservation, constructed for logistical support in World War II was scheduled to close. A museum has been proposed in a building that served as a morgue during the Vietnam War in the 1960s. The Palama fire station at 879 North King Street was added to the National Register of Historic Places listings in Oahu as site 76000661 April 21, 1976 along with other Fire Stations of Oahu. It was designed in 1901 by Oliver G. Traphagen.
The Kaumakapili Church was moved to 766 North King Street after the 1900 fire in Chinatown. It was originally established on April 1, 1838 as a Protestant church for common people, to supplement the Kawaiahao Church which was generally intended for nobility. From 1881 to 1888 a new brick and wood frame structure was built. Temporary services were held until the new structure was built. Ground was broken on May 7, 1910 and the new building dedicated on June 25, 1911. It is located at the southern end of Palama Street at  After much damage through the years, members raised US$2.4 million for a renovation starting in 1993 of the Gothic Revival architecture building.
Peter Cushman Jones established a Palama Chapel in the area in 1896. After the 1900 fire, James Arthur and Ragna Helsher Rath added social services to the center and called it Palama Settlement. The center, located at 810 North Vineyard Boulevard at Palama Street continues to offer community recreation and educational programs. The martial art of Kajukenbo was developed at the Palama Settlement.
- U.S. Geological Survey Geographic Names Information System: Kapālama
- Lloyd J. Soehren (2004). "lookup of Kapalama". on Hawaiian place names. Ulukau, the Hawaiian Electronic Library. Retrieved August 25, 2010.
- Mary Kawena Pukui and Elbert (2003). "lookup of lama". on Hawaiian dictionary. Ulukau, the Hawaiian Electronic Library, University of Hawaii. Retrieved August 25, 2010.
- "Kapālama Campus". official web site. Kamehameha Schools. Retrieved August 25, 2010.
- U.S. Geological Survey Geographic Names Information System: Kapālama Stream
- U.S. Geological Survey Geographic Names Information System: Kapālama Drainage Canal
- "Enhanced Preliminary Assessment, Kapalama Military Reservation, Honolulu, Hawaii". US Defense Technical Information Center web site. February 1990. Retrieved August 25, 2010.
- William Cole (March 24, 2008). "Some seek to preserve former morgue". Honolulu Advertiser. Retrieved August 25, 2010.
- "National Register Information System". National Register of Historic Places. National Park Service. 2009-03-13.
- "History of Kaumakapili Church". Kaumakapili Church. Retrieved December 27, 2013.
- "Kaumakapili Church Restoration". Mason Architects. Archived from the original on February 4, 2011. Retrieved December 27, 2013.
- Mike Gordon (July 2, 2006). "Palama Settlement". Honolulu Advertiser. Retrieved August 25, 2010.
- "Palama Settlement". official web site. January 2010. Retrieved August 25, 2010.
- John Evan Bishop (2006). Kajukenbo —the Original Mixed Martial Art. p. 20. ISBN 978-1-59872-609-1.