He comes from Sunderland, England, but established himself in the Sheffield music scene, most notably with the funk band Chakk whose advance from MCA Records financed the building of FON Studios. Before its bankruptcy, Brydon had divested himself of his interests in legendary FON Studios, for which he did everything from designing the studio architecture to hand-choosing equipment.
His biggest contribution to British art pop to date would come as a result of meeting Róisín Murphy, with whom he formed Moloko, at a cocktail party. The two hit off immediately, and began working together first as a duo for two albums, then bringing in a full line-up to tour and record the last two Moloko albums. Moloko went on indefinite hiatus after the release of Statues in 2003, followed by a successful tour and the release of the full length concert video 11,000 Clicks in 2004 (filmed at their final performance in Brixton, at the end of the Statues tour).
Following Moloko's indefinite break-up, Brydon focused his energies on the design of a new studio. He also continues a side career as a remixer under such aliases as DJ Plankton.