Between Northampton and Market Harborough it follows the route of a disused railway line, passing through two tunnels. The Midshires Way starts from Pulpit Hill, near Little Kimble and runs to Stockport, a total length of 230 miles, with 46 miles in Northamptonshire. One section within Northampton runs closely to the Grand Union Canal at Blisworth Junction in Rothersthorpe, Northampton.
The route was opened in 1994 as a collaboration between numerous Local Authorities and user groups. It is intended as a multi-user trail but there are places where the recommended route for walkers differs from the route for horse riders and cyclists.