N-acetyl-gamma-glutamyl-phosphate reductase

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N-acetyl-gamma-glutamyl-phosphate reductase
Identifiers
EC number 1.2.1.38
CAS number 37251-00-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) is an enzyme that catalyzes the chemical reaction

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate \rightleftharpoons N-acetyl-L-glutamyl 5-phosphate + NADPH + H+

The 3 substrates of this enzyme are N-acetyl-L-glutamate 5-semialdehyde, NADP+, and phosphate, whereas its 3 products are N-acetyl-L-glutamyl 5-phosphate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating). Other names in common use include reductase, acetyl-gamma-glutamyl phosphate, N-acetylglutamate 5-semialdehyde dehydrogenase, N-acetylglutamic gamma-semialdehyde dehydrogenase, N-acetyl-L-glutamate gamma-semialdehyde:NADP+ oxidoreductase, and (phosphorylating). This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies[edit]

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1VKN, 2CVO, 2G17, 2I3A, 2I3G, 2NQT, 2OZP, and 2Q49.

References[edit]

  • BAICH A, VOGEL HJ (1962). "N-Acetyl-gamma-Ilutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: repressible enzymes of arginine synthesis in Escherichia coli". Biochem. Biophys. Res. Commun. 7: 491–6. doi:10.1016/0006-291X(62)90342-X. PMID 13863980. 
  • Glansdorff N and Sand G (1965). "Coordination of enzyme synthesis in the arginine pathway of Escherichia coli K-12". Biochim. Biophys. Acta 108: 308–311. doi:10.1016/0005-2787(65)90016-x.