NPR3

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Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NPR3 ; ANP-C; ANPR-C; ANPRC; C5orf23; GUCY2B; NPR-C; NPRC
External IDs OMIM108962 MGI97373 HomoloGene699 GeneCards: NPR3 Gene
Orthologs
Species Human Mouse
Entrez 4883 18162
Ensembl ENSG00000113389 ENSMUSG00000022206
UniProt P17342 P70180
RefSeq (mRNA) NM_000908 NM_001039181
RefSeq (protein) NP_000899 NP_001034270
Location (UCSC) Chr 5:
32.69 – 32.79 Mb
Chr 15:
11.84 – 11.91 Mb
PubMed search [1] [2]

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR3 gene.[1]

Function[edit]

The family of natriuretic peptides elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.