Calcitonin receptor

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Calcitonin receptor
Identifiers
Symbols CALCR ; CRT; CT-R; CTR; CTR1
External IDs OMIM114131 MGI101950 HomoloGene1320 IUPHAR: CT receptor ChEMBL: 1832 GeneCards: CALCR Gene
RNA expression pattern
PBB GE CALCR 207886 s at tn.png
PBB GE CALCR 207887 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 799 12311
Ensembl ENSG00000004948 ENSMUSG00000023964
UniProt P30988 Q60755
RefSeq (mRNA) NM_001164737 NM_001042725
RefSeq (protein) NP_001158209 NP_001036190
Location (UCSC) Chr 7:
93.05 – 93.2 Mb
Chr 6:
3.69 – 3.76 Mb
PubMed search [1] [2]

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis,[1] particularly with respect to bone formation and metabolism.[2][3][4]

CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain.[5] It may also affect the ovaries in women and the testes in men.

The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).[6]

Interactions[edit]

Calcitonin receptor has been shown to interact with Apolipoprotein B[7][8] and LRP1.[9]

References[edit]

  1. ^ Purdue BW, Tilakaratne N, Sexton PM (2002). "Molecular pharmacology of the calcitonin receptor". Recept. Channels 8 (3–4): 243–55. doi:10.1080/10606820213681. PMID 12529940. 
  2. ^ Chambers TJ, Magnus CJ (1982). "Calcitonin alters behaviour of isolated osteoclasts". J. Pathol. 136 (1): 27–39. doi:10.1002/path.1711360104. PMID 7057295. 
  3. ^ Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, Karsenty G (2004). "Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo". J. Cell Biol. 164 (4): 509–514. doi:10.1083/jcb.200312135. PMC 2171986. PMID 14970190. 
  4. ^ Davey RA, Turner A, McManus JF, Chiu WS, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C, Glatt V, Maclean HE, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD (2008). "Calcitonin Receptor Plays a Physiological Role to Protect Against Hypercalcemia in Mice". J Bone Miner Res 23 (8): 1182–1193. doi:10.1359/jbmr.080310. PMC 2680171. PMID 18348688. 
  5. ^ senselab
  6. ^ "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  7. ^ Zhang, Jianying; Herscovitz Haya (Feb 2003). "Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B". J. Biol. Chem. (United States) 278 (9): 7459–68. doi:10.1074/jbc.M207976200. ISSN 0021-9258. PMID 12397072. 
  8. ^ Linnik, K M; Herscovitz H (Aug 1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". J. Biol. Chem. (UNITED STATES) 273 (33): 21368–73. doi:10.1074/jbc.273.33.21368. ISSN 0021-9258. PMID 9694898. 
  9. ^ Orr, Anthony Wayne; Pedraza Claudio E, Pallero Manuel Antonio, Elzie Carrie A, Goicoechea Silvia, Strickland Dudley K, Murphy-Ullrich Joanne E (Jun 2003). "Low density lipoprotein receptor–related protein is a calreticulin coreceptor that signals focal adhesion disassembly". J. Cell Biol. (United States) 161 (6): 1179–89. doi:10.1083/jcb.200302069. ISSN 0021-9525. PMC 2172996. PMID 12821648. 

Further reading[edit]

External links[edit]