Type I are cytokine receptors transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name , and share a common hemopoietin receptors amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.
Signal transduction chains [ edit ]
The signal transducing chains are often shared between different receptors within this receptor family.
The common beta chain (
CD131 or CDw131) is shared between the following type I cytokine receptors:
The gp230 receptor
common gamma chain (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
Examples [ edit ]
Type I cytokine receptors include
interleukin receptors, colony stimulating factor receptors and other cytokine receptors
Interleukin receptors [ edit ]
Colony stimulating factor receptors [ edit ]
Hormone receptor/neuropeptide receptor [ edit ]
References [ edit ]
^ Lichtman, Andrew H.; Abbas, Abul K. (2003). Cellular and molecular immunology (5th ed.). Philadelphia: Saunders. ISBN 0-7216-0008-5.
^ He YW, Adkins B, Furse RK, Malek TR (1995). "Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor". J. Immunol. 154 (4): 1596–605. PMID 7530740.
^ Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF (1998). "Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors". J. Biol. Chem. 273 (2): 1192–9. doi: 10.1074/jbc.273.2.1192. PMID 9422786.
External links [ edit ]