Negative electron-transfer dissociation

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Negative electron-transfer dissociation (NETD) is an ion/ion reaction in which an electron from an anionic species is transferred to cationic reagent.[1] Following this transfer event, the electron deficient anion undergoes internal rearrangement and fragments. NETD is the ion/ion analogue of electron-detachment dissociation (EDD).

Peptide fragmentation mechanism[edit]

NETD is compatible with fragmenting peptide and proteins along the backbone at the Cα-C bond. The resulting fragments are usually a- and x-type product ions.

See also[edit]


  1. ^ Coon JJ, Shabanowitz J, Hunt DF, Syka JE (June 2005). "Electron transfer dissociation of peptide anions". J. Am. Soc. Mass Spectrom. 16 (6): 880–2. doi:10.1016/j.jasms.2005.01.015. PMID 15907703.