Santa Cruz (O'odham: Hia-t-ab) is a census-designated place (CDP) in Pinal County, Arizona, United States, located in the Gila River Indian Community. The population was 37 at the 2010 census.
As of the census of 2010, there were 37 people residing in the CDP. The population density was 22.7 people per square mile. The racial makeup of the CDP was 97.30% Native American and 2.70% from other races. 8.11% of the population were Hispanic or Latino of any race.
Coordinates: 33°13′58″N 112°09′34″W / 33.23278°N 112.15944°W