Sincalide

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Sincalide
Sincalide.svg
Systematic (IUPAC) name
α-aspartyl-O-sulfotyrosylmethionylglycyltryptophylmethionyl-α-aspartylphenylalaninamide
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat. B (US)
Legal status -only (US) Available on a named-patient basis (UK)
Routes Intravenous
Identifiers
CAS number 25126-32-3 YesY
ATC code V04CC03
PubChem CID 32800
IUPHAR ligand 864
UNII M03GIQ7Z6P N
KEGG D05845 YesY
ChEMBL CHEMBL1121 N
Synonyms 1-De(5-oxo-L-proline)-2-de-L-glutamine-
5-L-methioninecaerulein, 3-[[2-[[2-[[2-[[2-[[2-[(2-amino-3-carboxy-propanoyl)
amino]-3-(4-sulfooxyphenyl)propanoyl]amino]-4-
methylsulfanyl-butanoyl]amino]acetyl]amino]-3-
(1H-indol-3-yl)propanoyl]amino]-4-methylsulfanyl-
butanoyl]amino]-3-[(1-carbamoyl-2-phenyl-ethyl)
carbamoyl]propanoic acid
Chemical data
Formula C49H62N10O16S3 
Mol. mass 1143.27 g/mol
 N (what is this?)  (verify)

Sincalide (INN) is a cholecystokinetic drug administered by injection to aid in diagnosing disorders of the gallbladder and pancreas. It is the 8-amino acid C-terminal fragment of cholecystokinin, and also known as CCK-8.

Common adverse effects following administration include abdominal discomfort and nausea. These effects are more pronounced following rapid infusion.

Clinical Use[edit]

Indications[edit]

Sincalide may be used to stimulate gallbladder contraction, as may be assessed by contrast agent cholecystography or ultrasonography, or to obtain by duodenal aspiration a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids, and crystals. It can also be used to stimulate pancreatic secretion (especially in conjunction with secretin) prior to obtaining a duodenal aspirate for analysis of enzyme activity, composition, and cytology. In some instances it is used to accelerate the transit of a barium meal through the small bowel, thereby decreasing the time and-extent of radiation associated with fluoroscopy and x-ray examination of the intestinal tract.[1]

External links[edit]

References[edit]

  1. ^ Kinevac Package Insert