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'''Premature ejaculation''' (initialized as '''PE'''; also known as '''rapid ejaculation''', '''rapid climax''', '''premature climax''', or '''early ejaculation''') affects 25%-40% of men in the U.S.
'''Premature ejaculation''' (initialized as '''PE'''; also known as '''rapid ejaculation''', '''rapid climax''', '''premature climax''', or '''early ejaculation''') affects 25%-40% of men in the U.S.
[[Masters and Johnson]] stated that a man suffers from premature [[ejaculation]] if he ejaculates before his sex partner achieves [[orgasm]] in more than fifty percent of their sexual encounters. Other [[sex researchers]] have defined premature ejaculation as occurring if the man ejaculates within two minutes of [[Sexual penetration|penetration]]; however, a survey by [[Alfred Kinsey]] in the 1950s demonstrated that three quarters of men ejaculate within two minutes of penetration in over half of their sexual encounters.{{Fact|date=September 2008}}. Self reported surveys report up to 75% of men ejaculate within 10 minutes of penetration [http://www.themaleclinic.co.uk] Today, most sex therapists understand premature ejaculation as occurring when a lack of ejaculatory control interferes with sexual or emotional well-being in one or both partners. {{Fact|date=September 2008}}
[[Masters and Johnson]] stated that a man suffers from premature [[ejaculation]] if he ejaculates before his sex partner achieves [[orgasm]] in more than fifty percent of their sexual encounters. Other [[sex researchers]] have defined premature ejaculation as occurring if the man ejaculates within two minutes of [[Sexual penetration|penetration]]; however, a survey by [[Alfred Kinsey]] in the 1950s demonstrated that three quarters of men ejaculate within two minutes of penetration in over half of their sexual encounters.{{Fact|date=September 2008}}. Self reported surveys report up to 75% of men ejaculate within 10 minutes of penetration. Today, most sex therapists understand premature ejaculation as occurring when a lack of ejaculatory control interferes with sexual or emotional well-being in one or both partners. {{Fact|date=September 2008}}




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Psychological factors commonly contribute to premature ejaculation. While men sometimes underestimate the relationship between sexual performance and emotional well-being, premature ejaculation can be caused by temporary [[clinical depression|depression]], stress over financial matters, unrealistic expectations about performance, a history of [[sexual repression (psychology)|sexual repression]], or an overall lack of confidence. Interpersonal dynamics strongly contribute to sexual function, and premature ejaculation can be caused by a lack of communication between partners, hurt feelings, or unresolved conflicts that interfere with the ability to achieve [[emotion]]al intimacy. Neurological premature ejaculation can also lead to other forms of [[sexual dysfunction]], or intensify the existing problem, by creating performance anxiety. In a less pathological context, premature ejaculation could also be caused simply by extreme arousal.
Psychological factors commonly contribute to premature ejaculation. While men sometimes underestimate the relationship between sexual performance and emotional well-being, premature ejaculation can be caused by temporary [[clinical depression|depression]], stress over financial matters, unrealistic expectations about performance, a history of [[sexual repression (psychology)|sexual repression]], or an overall lack of confidence. Interpersonal dynamics strongly contribute to sexual function, and premature ejaculation can be caused by a lack of communication between partners, hurt feelings, or unresolved conflicts that interfere with the ability to achieve [[emotion]]al intimacy. Neurological premature ejaculation can also lead to other forms of [[sexual dysfunction]], or intensify the existing problem, by creating performance anxiety. In a less pathological context, premature ejaculation could also be caused simply by extreme arousal.


According to the theories developed by [[Wilhelm Reich]], premature ejaculation may be a consequence of a stasis of sexual energy in the pelvic musculature, which prevents the diffusion of such energy to other parts of the body.<ref>{{cite web |url=http://aruhea.wordpress.com/2009/02/04/premature-ejaculation/ |title=Aruhea Blog |accessdate=2009-02-06 |format= |work=}}</ref>
According to the theories developed by [[Wilhelm Reich]], premature ejaculation may be a consequence of a stasis of sexual energy in the pelvic musculature, which prevents the diffusion of such energy to other parts of the body.


One study of young married couples (Tullberg, 1999) reported that the husband's [[IELT]] seems to be affected by the phases of the wife's [[menstrual cycle]], the IELT tending to be shortest during the [[ovulation|fertile phase]]. Other studies suggest that young men with older female partners reach the ''ejaculatory threshold'' sooner, on average, than those whose partners are their own age or younger {{Fact|date=November 2007}}.
One study of young married couples (Tullberg, 1999) reported that the husband's [[IELT]] seems to be affected by the phases of the wife's [[menstrual cycle]], the IELT tending to be shortest during the [[ovulation|fertile phase]]. Other studies suggest that young men with older female partners reach the ''ejaculatory threshold'' sooner, on average, than those whose partners are their own age or younger {{Fact|date=November 2007}}.
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===Premature Ejaculation Diagnostic Tool (PE TEST)===
===Premature Ejaculation Diagnostic Tool (PE TEST)===


Pfizer Inc, together with leading Premature Ejaculation experts have developed a diagnostic tool to help physicians and patients diagnose this condition. The methodology and results were published several times in medical congresses and peer reviewed medical journals .<ref>{{cite journal |author=Symonds T, Perelman MA, Althof S, Giuliano F, Martin M, May K, Abraham L, Crossland A, Morris M|title=Development and validation of a premature ejaculation diagnostic tool|journal=Eur Urol. |volume=52: |issue=2 |pages=565-73|year=2007 |pmid=17275165 |doi=}}</ref><ref>{{cite journal |author=Althof S, Rosen R, Symonds T, Mundayat R, May K, Abraham L|title=Development and validation of a new questionnaire to assess sexual satisfaction, control, and distress associated with premature ejaculation.|journal=J Sex Med |volume=3 |issue=3 |pages=465-75 |year=2006 |pmid=16681472 |doi=}}</ref>. The diagnostic tool is available online at the PEhomepage.com website [http://www.pehomepage.com/premature_ejaculation_test_pfizer.asp]. The three different categories a patient can be classified to are: No PE; Probable PE; and PE.
Pfizer Inc, together with leading Premature Ejaculation experts have developed a diagnostic tool to help physicians and patients diagnose this condition. The methodology and results were published several times in medical congresses and peer reviewed medical journals .<ref>{{cite journal |author=Symonds T, Perelman MA, Althof S, Giuliano F, Martin M, May K, Abraham L, Crossland A, Morris M|title=Development and validation of a premature ejaculation diagnostic tool|journal=Eur Urol. |volume=52: |issue=2 |pages=565-73|year=2007 |pmid=17275165 |doi=}}</ref><ref>{{cite journal |author=Althof S, Rosen R, Symonds T, Mundayat R, May K, Abraham L|title=Development and validation of a new questionnaire to assess sexual satisfaction, control, and distress associated with premature ejaculation.|journal=J Sex Med |volume=3 |issue=3 |pages=465-75 |year=2006 |pmid=16681472 |doi=}}</ref>. The three different categories a patient can be classified to are: No PE; Probable PE; and PE.


===Differential diagnosis===
===Differential diagnosis===
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Another method is that of control instead of prevention. Performing routines such as [[Kegel exercises]], which, as mentioned above, relate to gaining voluntary control of the PC muscle and thus give a person more control over ejaculation. When ejaculating, the control of this muscle is said to be lost, and thus, learning to maintain control of it can be of aid to some.
Another method is that of control instead of prevention. Performing routines such as [[Kegel exercises]], which, as mentioned above, relate to gaining voluntary control of the PC muscle and thus give a person more control over ejaculation. When ejaculating, the control of this muscle is said to be lost, and thus, learning to maintain control of it can be of aid to some.

Additionally, new treatments include topical sprays. A brand new Over-The-Counter treatment is called Promescent http://www.promescent.com and it has been developed by Dr. Ronald Gilbert [http://www.nbneuro.com/], an attending Urological Surgeon at Hoag Hospital in Newport Beach [http://www.hoaghospital.org/], California. The application of Promescent [http://www.promescent.com] is simple enough, the male applies a spray of the product to the penis just prior to intercourse. Promescent temporarily delays the onset of ejaculation by reducing the hypersensitivity of the penis that often leads to premature ejaculation. Topical solutions avoid the negative side effects of more commonly prescribed treatments.


===Medications===
===Medications===
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[[William Francis Ganong (physiologist)|William Francis Ganong]] cited dietary [[5-HTP]] as an alternative source to raising serotonin levels. Many supplements are available that contain 5-HTP.
[[William Francis Ganong (physiologist)|William Francis Ganong]] cited dietary [[5-HTP]] as an alternative source to raising serotonin levels. Many supplements are available that contain 5-HTP.


Magnesium deficiency, very common in the Western world and especially in the United States, has been associated with premature ejaculation. <ref> See: 1. Seminal plasma magnesium and premature ejaculation: a case-control study. Nikoobakht MR, Aloosh M, Hasani M. Urol J. 2005 Spring;2(2):102-5. PMID: 17629880 [PubMed - in process], 2: Seminal plasma magnesium and premature ejaculation: a case-control study. Aloosh M, Hassani M, Nikoobakht M. BJU Int. 2006 Aug;98(2):402-4. PMID: 16879686 [PubMed - indexed for MEDLINE], 3: Proposals or findings for a new approach about how to define and diagnose premature ejaculation. Wang W, Kumar P, Minhas S, Ralph D. Eur Urol. 2005 Sep;48(3):418-23. Review. PMID: 15967566 [PubMed - indexed for MEDLINE], 4: Magnesium in human semen: possible role in premature ejaculation. Omu AE, Al-Bader AA, Dashti H, Oriowo MA. Arch Androl. 2001 Jan-Feb;46(1):59-66.</ref>
Medical grade topical anesthetics are a common ingredient in many over-the-counter products such as condoms and non-aerosol sprays.<ref>{{cite web |url=http://www.pe-tips.com/climax-control-condoms/ |title=Climax Control Condoms |accessdate=2008-09-30 |format= |work=}}</ref><ref>{{cite web |url=http://www.pe-tips.com/how-to-stop-premature-ejaculation-with-sprays-and-creams/ |title=How To Stop Premature Ejaculation With Sprays And Creams |accessdate=2008-09-30 |format= |work=}}</ref>

Magnesium deficiency, very common in the Western world and especially in the United States, has been associated with premature ejaculation. <ref> See: Seminal plasma magnesium and premature ejaculation: a case-control study.

Topical medications are a new generations of easy to use sprays that can delay rapid ejaculation. On a April 2009 [Today Show with Matt Lauer] http://today.msnbc.msn.com/id/26184891/vp/30105395#30105395, [NBC News' chief medical editor Dr. Nancy Snyderman]http://www.nlm.nih.gov/changingthefaceofmedicine/physicians/biography_302.html discussed an new type of product coming to market in the form of topical solutions. A new treatment available is Promescent. The formula in this new PE treatment delays ejaculation by eliminating the hypersensitivity that leads to premature ejaculation.
Nikoobakht MR, Aloosh M, Hasani M.

Urol J. 2005 Spring;2(2):102-5.

PMID: 17629880 [PubMed - in process]

2:

Seminal plasma magnesium and premature ejaculation: a case-control study.

Aloosh M, Hassani M, Nikoobakht M.

BJU Int. 2006 Aug;98(2):402-4.

PMID: 16879686 [PubMed - indexed for MEDLINE]

3:

Proposals or findings for a new approach about how to define and diagnose premature ejaculation.

Wang W, Kumar P, Minhas S, Ralph D.

Eur Urol. 2005 Sep;48(3):418-23. Review.

PMID: 15967566 [PubMed - indexed for MEDLINE]

4:

Magnesium in human semen: possible role in premature ejaculation.

Omu AE, Al-Bader AA, Dashti H, Oriowo MA.

Arch Androl. 2001 Jan-Feb;46(1):59-66.</ref>


== External Links ==
== External Links ==
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* [http://www.pehomepage.com/Treating-PE/Medications/Treatment_for_premature_ejaculation_Interview_with_Lead_Investigator_for_Dapoxetine_77.html "PEhomepage.com - treatments for premature ejaculation"] - an article on dapoxetine
* [http://www.webmd.com/content/article/127/116615.htm "Premature Ejaculation Drug Promising"]
* [http://www.webmd.com/content/article/127/116615.htm "Premature Ejaculation Drug Promising"]
* [http://www.msnbc.msn.com/id/8478505/ "The many mysteries of the female orgasm"] - An editorial about advances in sexual pharmacology
* [http://www.msnbc.msn.com/id/8478505/ "The many mysteries of the female orgasm"] - An editorial about advances in sexual pharmacology

Revision as of 04:35, 10 June 2009

Premature ejaculation
SpecialtyPsychiatry, psychology Edit this on Wikidata

Premature ejaculation (initialized as PE; also known as rapid ejaculation, rapid climax, premature climax, or early ejaculation) affects 25%-40% of men in the U.S. Masters and Johnson stated that a man suffers from premature ejaculation if he ejaculates before his sex partner achieves orgasm in more than fifty percent of their sexual encounters. Other sex researchers have defined premature ejaculation as occurring if the man ejaculates within two minutes of penetration; however, a survey by Alfred Kinsey in the 1950s demonstrated that three quarters of men ejaculate within two minutes of penetration in over half of their sexual encounters.[citation needed]. Self reported surveys report up to 75% of men ejaculate within 10 minutes of penetration. Today, most sex therapists understand premature ejaculation as occurring when a lack of ejaculatory control interferes with sexual or emotional well-being in one or both partners. [citation needed]


Most men experience premature ejaculation at least once in their lives. Because there is great variability in both how long it takes men to ejaculate and how long both partners want sex to last, researchers have begun to form a quantitative definition of premature ejaculation. Current evidence supports an average intravaginal ejaculation latency time of six and a half minutes in 18-30 year olds.[1][2] If the disorder is defined as an IELT percentile below 2.5, then premature ejaculation could be suggested by an IELT of less than about one and a half minutes.[3] Nevertheless, it is well accepted that men with IELTs below 1.5 minutes could be "happy" with their performance and do not report a lack of control and therefore do not suffer from PE. On the other hand, a man with 2 minutes IELT may have the perception of poor control over his ejaculation, distressed about his condition, has interpersonal difficulties and therefore be diagnosed with PE.

Possible psychological and environmental factors

Psychological factors commonly contribute to premature ejaculation. While men sometimes underestimate the relationship between sexual performance and emotional well-being, premature ejaculation can be caused by temporary depression, stress over financial matters, unrealistic expectations about performance, a history of sexual repression, or an overall lack of confidence. Interpersonal dynamics strongly contribute to sexual function, and premature ejaculation can be caused by a lack of communication between partners, hurt feelings, or unresolved conflicts that interfere with the ability to achieve emotional intimacy. Neurological premature ejaculation can also lead to other forms of sexual dysfunction, or intensify the existing problem, by creating performance anxiety. In a less pathological context, premature ejaculation could also be caused simply by extreme arousal.

According to the theories developed by Wilhelm Reich, premature ejaculation may be a consequence of a stasis of sexual energy in the pelvic musculature, which prevents the diffusion of such energy to other parts of the body.

One study of young married couples (Tullberg, 1999) reported that the husband's IELT seems to be affected by the phases of the wife's menstrual cycle, the IELT tending to be shortest during the fertile phase. Other studies suggest that young men with older female partners reach the ejaculatory threshold sooner, on average, than those whose partners are their own age or younger [citation needed].

Possible physical factors

Science of mechanism of ejaculation

The physical process of ejaculation requires two sequential actions: emission and expulsion.

Mechanism of Ejaculation

The emission phase is the first phase. It involves deposition of seminal fluid from the ampullary vas deferens, seminal vesicles, and prostate gland into the posterior urethra.[4] The second phase is the expulsion phase. It involves closure of bladder neck, followed by the rhythmic contractions of the urethra by pelvic-perineal and bulbospongiosus muscle, and intermittent relaxation of external urethral sphincters.[5]

It is believed that the neurotransmitter serotonin (5HT) plays a central role in modulating ejaculation. Several animal studies have demonstrated its inhibitory effect on ejaculation. Therefore, it is perceived that low level of serotonin in the synaptic cleft in these specific areas in the brain could cause premature ejaculation. This theory is further supported by the proven effectiveness of selective serotonin reuptake inhibitors (SSRIs), which increase serotonin level in the synapse, in treating PE.

Sympathetic motor neurons control the emission phase of ejaculation reflex, and expulsion phase is executed by somatic and autonomic motor neurons. These motor neurons are located in the thoracolumbar and lumbosacral spinal cord and are activated in a coordinated manner when sufficient sensory input to reach the ejaculatory threshold has entered the central nervous system.[6][7]

Several areas in the brain, and especially the nucleus paragigantocellularis, have been identified to be involved in ejaculatory control.[8] Scientists have long suspected a genetic link to certain forms of premature ejaculation. In one study, ninety-one percent of men who suffered from lifelong premature ejaculation also had a first-relative with lifelong premature ejaculation. Other researchers have noted that men who suffer from premature ejaculation have a faster neurological response in the pelvic muscles. Simple exercises commonly suggested by sex therapists can significantly improve ejaculatory control for men with premature ejaculation caused by neurological factors[citation needed]. Often, these men may benefit from anti-anxiety medication or SSRIs, such as sertraline or paroxetine, as these slow down ejaculation times[1]. Some men prefer using anaesthetic creams; however, these creams may also deaden sensations in the man's partner, and are not generally recommended by sex therapists.

Diagnosis

Diagnostic criteria for Premature Ejaculation DSM-IV-TR (American Psychiatric Association)

A. Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the person wishes it. The clinician must take into account factors that affect duration of the excitement phase, such as age, novelty of the sexual partner or situation, and recent frequency of sexual activity.

B. The disturbance causes marked distress or interpersonal difficulty.

C. The premature ejaculation is not due exclusively to the direct effects of a substance (e.g., withdrawal from opioids).

Premature Ejaculation Diagnostic Tool (PE TEST)

Pfizer Inc, together with leading Premature Ejaculation experts have developed a diagnostic tool to help physicians and patients diagnose this condition. The methodology and results were published several times in medical congresses and peer reviewed medical journals .[9][10]. The three different categories a patient can be classified to are: No PE; Probable PE; and PE.

Differential diagnosis

Premature ejaculation should be distinguished from erectile dysfunction related to the development of a general medical condition. Some individuals with erectile dysfunction may omit their usual strategies for delaying orgasm. Others require prolonged noncoital stimulation to develop a degree of erection sufficient for intromission. In such individuals, sexual arousal may be so high that ejaculation occurs immediately. Occasional problems with premature ejaculation that are not persistent or recurrent or are not accompanied by marked distress or interpersonal difficulty do not qualify for the diagnosis of premature ejaculation. The clinician should also take into account the individual's age, overall sexual experience, recent sexual activity, and the novelty of the partner. When problems with premature ejaculation are due exclusively to substance use (e.g., opioid withdrawal), a substance-induced sexual dysfunction can be diagnosed.

Ejaculation disorder types

  • Premature ejaculation - Ejaculation occurs very early
  • Delayed ejaculation - Ejaculation takes a long time
  • Retrograde ejaculation - Semen flows from the prostate gland into the bladder rather than exiting out of the penis.
  • Inhibited orgasm in males[11]

Treatment

In mundane cases, treatments are focused on gradually training and improving mental habituation to sex and physical development of stimulation control. In clinical cases, various medications are being tested to help slow down the speed of the arousal response.

Masters and Johnson recommended a start and stop technique to increase the time until ejaculation. This requires a great deal of couple cooperation and communication, and may be difficult for some.

Another method is that of control instead of prevention. Performing routines such as Kegel exercises, which, as mentioned above, relate to gaining voluntary control of the PC muscle and thus give a person more control over ejaculation. When ejaculating, the control of this muscle is said to be lost, and thus, learning to maintain control of it can be of aid to some.

Medications

Serotonergic medications, such as SSRIs, can delay ejaculation.[12][13] SSRIs are commonly used as anti-depressants. Examples include Prozac, Zoloft, Celexa, Effexor, and Lexapro. Clinical trials indicate that Paroxetine gives the largest increase in intravaginal ejaculation latency time.[14] Clomipramine often helps with serious cases that are related to the central nervous system (as opposed to psychological factors). The drug has the added benefit of also improving erection quality in some patients.[15]

William Francis Ganong cited dietary 5-HTP as an alternative source to raising serotonin levels. Many supplements are available that contain 5-HTP.

Magnesium deficiency, very common in the Western world and especially in the United States, has been associated with premature ejaculation. [16]

References

  1. ^ "Ejaculation delay: what's normal? [July 2005; 137-4]". Retrieved 2007-10-21.
  2. ^ Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M (2005). "A multinational population survey of intravaginal ejaculation latency time". The journal of sexual medicine. 2 (4): 492–7. doi:10.1111/j.1743-6109.2005.00070.x. PMID 16422843.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH (2005). "Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data". The journal of sexual medicine. 2 (4): 498–507. doi:10.1111/j.1743-6109.2005.00069.x. PMID 16422844.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Böhlen D, Hugonnet CL, Mills RD, Weise ES, Schmid HP (2000). "Five meters of H(2)O: the pressure at the urinary bladder neck during human ejaculation". Prostate. 44 (4): 339–41. doi:10.1002/1097-0045(20000901)44:4<339::AID-PROS12>3.0.CO;2-Z. PMID 10951500.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ Master VA, Turek PJ (2001). "Ejaculatory physiology and dysfunction". Urol. Clin. North Am. 28 (2): 363–75, x. doi:10.1016/S0094-0143(05)70145-2. PMID 11402588.
  6. ^ deGroat WC, Booth AM (1980). "Physiology of male sexual function". Ann. Intern. Med. 92 (2 Pt 2): 329–31. PMID 7356224.
  7. ^ Truitt WA, Coolen LM (2002). "Identification of a potential ejaculation generator in the spinal cord". Science. 297 (5586): 1566–9. doi:10.1126/science.1073885. PMID 12202834.
  8. ^ Coolen LM, Olivier B, Peters HJ, Veening JG (1997). "Demonstration of ejaculation-induced neural activity in the male rat brain using 5-HT1A agonist 8-OH-DPAT". Physiol. Behav. 62 (4): 881–91. doi:10.1016/S0031-9384(97)00258-8. PMID 9284512.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Symonds T, Perelman MA, Althof S, Giuliano F, Martin M, May K, Abraham L, Crossland A, Morris M (2007). "Development and validation of a premature ejaculation diagnostic tool". Eur Urol. 52: (2): 565–73. PMID 17275165.{{cite journal}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)
  10. ^ Althof S, Rosen R, Symonds T, Mundayat R, May K, Abraham L (2006). "Development and validation of a new questionnaire to assess sexual satisfaction, control, and distress associated with premature ejaculation". J Sex Med. 3 (3): 465–75. PMID 16681472.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ^ "Premature Ejaculation". Premature Ejaculation and Male Orgasmic Disorder. Armenian Medical Network. 2006. Retrieved 2007-09-19. {{cite web}}: Text "Adam Keller Ashton, M.D. Carolyn M. Young, M.D. Joseph LoPiccolo, Ph.D." ignored (help)
  12. ^ Safarinejad, M. R., & Hosseini, S. Y. (2006). Pharmacotherapy for premature ejaculation. Current Drug Therapy, 1, 37-46.
  13. ^ SadeghiNejad, H., & Watson, R. (2008). Premature ejaculation: Current medical treatment and new directions. Journal of Sexual Medicine, 5, 1037-1050.
  14. ^ Bandolier (2004). "Premature ejaculation treatments reviewed": 128–3. {{cite journal}}: Cite journal requires |journal= (help)
  15. ^ http://mayoclinic.com/health/drug-information/DR602715#89DB9B50-CC99-270F-FF4D198198E465E1
  16. ^ See: 1. Seminal plasma magnesium and premature ejaculation: a case-control study. Nikoobakht MR, Aloosh M, Hasani M. Urol J. 2005 Spring;2(2):102-5. PMID: 17629880 [PubMed - in process], 2: Seminal plasma magnesium and premature ejaculation: a case-control study. Aloosh M, Hassani M, Nikoobakht M. BJU Int. 2006 Aug;98(2):402-4. PMID: 16879686 [PubMed - indexed for MEDLINE], 3: Proposals or findings for a new approach about how to define and diagnose premature ejaculation. Wang W, Kumar P, Minhas S, Ralph D. Eur Urol. 2005 Sep;48(3):418-23. Review. PMID: 15967566 [PubMed - indexed for MEDLINE], 4: Magnesium in human semen: possible role in premature ejaculation. Omu AE, Al-Bader AA, Dashti H, Oriowo MA. Arch Androl. 2001 Jan-Feb;46(1):59-66.

[2]

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