Orotic acid: Difference between revisions
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| CAS_number = 65-86-1 |
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'''Orotic acid''' is a [[heterocyclic compound]] and an [[acid]]; it is also known as '''pyrimidinecarboxylic acid'''. Historically, it was believed to be part of the [[vitamin B]] complex and was called '''vitamin |
'''Orotic acid''' is a [[heterocyclic compound]] and an [[acid]]; it is also known as '''pyrimidinecarboxylic acid'''. Historically, it was believed to be part of the [[vitamin B]] complex and was called '''vitamin B<sub>13</sub>''', but it is now known that it is not a [[vitamin]], but is instead manufactured in the body by [[intestinal flora]].{{fact|date=July 2009}} |
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Its salts, known as orotates, are sometimes used as [[mineral carrier]]s in some [[dietary supplements]], to increase their [[bioavailability]]. [[Lithium orotate]] is the most frequently used in this manner. |
Its salts, known as orotates, are sometimes used as [[mineral carrier]]s in some [[dietary supplements]], to increase their [[bioavailability]]. [[Lithium orotate]] is the most frequently used in this manner. |
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* [[Pyrimidine biosynthesis]] |
* [[Pyrimidine biosynthesis]] |
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==References== |
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==External links== |
==External links== |
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[[Category:Pyrimidines]] |
[[Category:Pyrimidines]] |
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{{Nucleotide metabolism intermediates}} |
{{Nucleotide metabolism intermediates}} |
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[[pl:Kwas orotowy]] |
[[pl:Kwas orotowy]] |
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[[pt:Ácido orótico]] |
[[pt:Ácido orótico]] |
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J. Am. Chem. Soc., 1954, 76 (23), pp 6052–6054 |
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Revision as of 11:37, 31 July 2009
 | This article needs additional citations for verification. (October 2007) |
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| ATC code |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.563 |
| Chemical and physical data | |
| Formula | C5H4N2O4 |
| Molar mass | 156.10 g/mol g·mol−1 |
Orotic acid is a heterocyclic compound and an acid; it is also known as pyrimidinecarboxylic acid. Historically, it was believed to be part of the vitamin B complex and was called vitamin B13, but it is now known that it is not a vitamin, but is instead manufactured in the body by intestinal flora.[citation needed]
Its salts, known as orotates, are sometimes used as mineral carriers in some dietary supplements, to increase their bioavailability. Lithium orotate is the most frequently used in this manner.
Pathology
A buildup can lead to orotic aciduria.
In ornithine transcarbamoylase deficiency, a disorder of the urea cycle, excess carbamoyl phospate is converted into orotic acid. This typically leads to increased urinary orotic acid excretion.
See also
References
- Orotic Acid antagonist: "6-Uracilsulfonic Acid, a Sulronic Acid Analog of Orotic Acid" Sheldon B. Greenbaum, J. Am. Chem. Soc., 1954, 76 (23), pp 6052–6054
External links
- Orotic+Acid at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview at ggc.org
- Overview at greatvistachemicals.com
- Overview of Potential Metabolic Antagonists
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