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==References== |
==References== |
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==External Links== |
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* [http://www.mapkinases.eu MAP Kinase Resource ]. |
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== Further reading == |
== Further reading == |
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Revision as of 16:25, 17 July 2011
Template:PBB Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.[1][2]
Function
MAPK7 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor tyrosine kinases, and G protein-coupled receptors. In response to extracellular signals, this kinase translocates to the cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.[3]
MAPK7 is also critical for cardiovascular development [4] and is essential for endothelial cell function.[5] [6]
Interactions
MAPK7 has been shown to interact with SGK,[7] MEF2C,[8] YWHAB,[9] MEF2D,[8] C-Raf,[10] PTPRR,[11] Gap junction protein, alpha 1[12] and MAP2K5.[2]
References
- ^ Purandare SM, Lee JD, Patel PI (1999). "Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids". Cytogenet Cell Genet. 83 (3–4): 258–9. doi:10.1159/000015199. PMID 10072598.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b Zhou G, Bao ZQ, Dixon JE (1995). "Components of a new human protein kinase signal transduction pathway". J Biol Chem. 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) Cite error: The named reference "pmid7759517" was defined multiple times with different content (see the help page). - ^ "Entrez Gene: MAPK7 mitogen-activated protein kinase 7".
- ^ Hayashi M, Lee JD. (2004). "Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice". J Mol Med. 82 (12): 800–8. doi:10.1007/s00109-004-0602-8. PMID 15517128.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ. (2009). "ERK5 and the regulation of endothelial cell function". Biochem Soc Trans. 37 (6): 1254–9. doi:10.1042/BST0371254. PMID 19909257.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ. (2010). "ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells". J Cell Sci. 123 (18): 3189–3200. doi:10.1242/jcs.072801. PMID 20736307.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Hayashi, M (2001). "BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase". J. Biol. Chem. 276 (12). United States: 8631–4. doi:10.1074/jbc.C000838200. ISSN 0021-9258. PMID 11254654.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link) - ^ a b Yang, C C (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. 26 (20). ENGLAND: 4771–7. doi:10.1093/nar/26.20.4771. ISSN 0305-1048. PMC 147902. PMID 9753748.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: year (link) - ^ Zheng, Qinlei (2004). "14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function". J. Biol. Chem. 279 (10). United States: 8787–91. doi:10.1074/jbc.M310212200. ISSN 0021-9258. PMID 14679215.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link) - ^ English, J M (1999). "Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control". J. Biol. Chem. 274 (44). UNITED STATES: 31588–92. doi:10.1074/jbc.274.44.31588. ISSN 0021-9258. PMID 10531364.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link) - ^ Buschbeck, Marcus (2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway". J. Biol. Chem. 277 (33). United States: 29503–9. doi:10.1074/jbc.M202149200. ISSN 0021-9258. PMID 12042304.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link) - ^ Cameron, Scott J (2003). "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation". J. Biol. Chem. 278 (20). United States: 18682–8. doi:10.1074/jbc.M213283200. ISSN 0021-9258. PMID 12637502.
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External Links
Further reading
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