MAPK7

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MAPK7
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAPK7, BMK1, ERK4, ERK5, PRKM7, mitogen-activated protein kinase 7
External IDs MGI: 1346347 HomoloGene: 2060 GeneCards: 5598
RNA expression pattern
PBB GE MAPK7 207292 s at tn.png

PBB GE MAPK7 35617 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002749
NM_139032
NM_139033
NM_139034

RefSeq (protein)

NP_002740.2
NP_620601.1
NP_620602.2
NP_620603.2

Location (UCSC) Chr 17: 19.38 – 19.38 Mb Chr 11: 61.49 – 61.49 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.[1][2]

Function[edit]

MAPK7 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor tyrosine kinases, and G protein-coupled receptors. In response to extracellular signals, this kinase translocates to the cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.[3]

MAPK7 is also critical for cardiovascular development [4] and is essential for endothelial cell function.[5][6]

Interactions[edit]

MAPK7 has been shown to interact with:

References[edit]

  1. ^ Purandare SM, Lee JD, Patel PI (March 1999). "Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids". Cytogenet. Cell Genet. 83 (3-4): 258–9. doi:10.1159/000015199. PMID 10072598. 
  2. ^ a b Zhou G, Bao ZQ, Dixon JE (Jun 1995). "Components of a new human protein kinase signal transduction pathway". J. Biol. Chem. 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517. 
  3. ^ "Entrez Gene: MAPK7 mitogen-activated protein kinase 7". 
  4. ^ Hayashi M, Lee JD (Oct 2004). "Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice". J. Mol. Med. 82 (12): 800–8. doi:10.1007/s00109-004-0602-8. PMID 15517128. 
  5. ^ Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ (Dec 2009). "ERK5 and the regulation of endothelial cell function". Biochem. Soc. Trans. 37 (Pt 6): 1254–9. doi:10.1042/BST0371254. PMID 19909257. 
  6. ^ Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ (Sep 2010). "ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells". J. Cell. Sci. 123 (Pt 18): 3189–200. doi:10.1242/jcs.072801. PMID 20736307. 
  7. ^ English JM, Pearson G, Hockenberry T, Shivakumar L, White MA, Cobb MH (Oct 1999). "Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control". J. Biol. Chem. 274 (44): 31588–92. doi:10.1074/jbc.274.44.31588. PMID 10531364. 
  8. ^ Cameron SJ, Malik S, Akaike M, Lerner-Marmarosh N, Yan C, Lee JD, Abe J, Yang J (May 2003). "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation". J. Biol. Chem. 278 (20): 18682–8. doi:10.1074/jbc.M213283200. PMID 12637502. 
  9. ^ a b Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. 26 (20): 4771–7. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748. 
  10. ^ Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (Aug 2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway". J. Biol. Chem. 277 (33): 29503–9. doi:10.1074/jbc.M202149200. PMID 12042304. 
  11. ^ Hayashi M, Tapping RI, Chao TH, Lo JF, King CC, Yang Y, Lee JD (Mar 2001). "BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase". J. Biol. Chem. 276 (12): 8631–4. doi:10.1074/jbc.C000838200. PMID 11254654. 
  12. ^ Zheng Q, Yin G, Yan C, Cavet M, Berk BC (Mar 2004). "14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function". J. Biol. Chem. 279 (10): 8787–91. doi:10.1074/jbc.M310212200. PMID 14679215. 

Further reading[edit]

External links[edit]