Jump to content

E. Wesley Ely: Difference between revisions

Add links
From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
Citation bot (talk | contribs)
Bots
5,158,633 edits
Add: newspaper, s2cid, pmid, doi-access. Removed proxy/dead URL that duplicated identifier. Removed parameters. Some additions/deletions were parameter name changes. | Use this bot. Report bugs. | Suggested by Headbomb | Linked from Wikipedia:WikiProject_Academic_Journals/Journals_cited_by_Wikipedia/Sandbox | #UCB_webform_linked 176/847
No edit summary
Line 5: Line 5:
| image = E. Wesley Ely.png
| image = E. Wesley Ely.png
| education = [[Tulane University]]<br>[[Tulane University School of Public Health and Tropical Medicine|School of Public Health]]<br>[[Tulane University School of Medicine|Tulane University Medicine]]
| education = [[Tulane University]]<br>[[Tulane University School of Public Health and Tropical Medicine|School of Public Health]]<br>[[Tulane University School of Medicine|Tulane University Medicine]]
| employer = [[Vanderbilt University Medical Center]]
| employer = {{ubl|[[Vanderbilt University Medical Center]]|[[U.S. Department of Veteran's Affairs]]}}
| known_for = ICU [[delirium]] and post-ICU [[dementia]] research
| known_for = ICU [[delirium]] and post-ICU [[dementia]] research
| website = {{URL|https://www.icudelirium.org}}
| website = {{URL|https://www.icudelirium.org}}
}}
}}'''Eugene Wesley Ely Jr.''' is an American physician and professor of medicine as the [[Grant Liddle|Grant W. Liddle]] Endowed Chair at [[Vanderbilt University School of Medicine]]. He is conducting research as a geriatric [[intensivist]] in the Division of [[Pulmonary medicine|Pulmonary]] and [[Critical care medicine|Critical Care Medicine]] and the Center for Health Services Research at [[Vanderbilt University Medical Center]]. He is also the associate director of research at the Tennessee Valley Geriatric Research Education and Clinical Center (GRECC), part of the [[United States Department of Veterans Affairs|U.S. Department of Veterans Affairs]].<ref name=":7">{{Cite journal|date=2017-04-01|editor-last=Napolitano|editor-first=Lena M.|editor2-last=Kellum|editor2-first=John A.|title=Contributors|url=http://www.criticalcare.theclinics.com/article/S0749-0704(17)30006-4/fulltext|journal=Critical Care Clinics|language=en|volume=33|issue=2|pages=iii–v|doi=10.1016/S0749-0704(17)30006-4|doi-access=free}}</ref><ref name=":8">{{Cite web|url=https://www.va.gov/GRECC/Tennessee_Valley_GRECC.asp|title=Tennessee Valley GRECC - Geriatric Research Education and Clinical Centers|last1=Foley|first1=Tim|date=2010-03-30|website=U.S. Department of Veterans Affair|language=en|access-date=2017-09-29}}</ref><ref>{{Cite web |last1=Kumar |first1=Ajoy |last2=Gabbard |first2=Erika |last3=Smith |first3=Heidi AB |last4=Vedral-Baron |first4=Jennifer |last5=Aldrich |first5=Matt |last6=Ely |first6=E. Wesley |date=December 21, 2017 |title=ICU liberation: Optimizing quality and efficiency of critical care delivery |url=https://www.beckershospitalreview.com/quality/icu-liberation-optimizing-quality-and-efficiency-of-critical-care-delivery.html |access-date=2017-12-26 |website=Beckers Hospital Review |language=en-US}}</ref>
'''Eugene Wesley Ely Jr.''' is an American physician, writer, and professor of medicine who serves as the [[Grant Liddle|Grant W. Liddle]] Endowed Chair at [[Vanderbilt University School of Medicine]]. He is conducting research as a geriatric [[intensivist]] in the Division of [[Pulmonary medicine|Pulmonary]] and [[Critical care medicine|Critical Care Medicine]] and the Center for Health Services Research at [[Vanderbilt University Medical Center]]. He is also the associate director of research at the Tennessee Valley Geriatric Research Education and Clinical Center (GRECC), part of the [[United States Department of Veterans Affairs|U.S. Department of Veterans Affairs]].<ref name=":7">{{Cite journal|date=2017-04-01|editor-last=Napolitano|editor-first=Lena M.|editor2-last=Kellum|editor2-first=John A.|title=Contributors|url=http://www.criticalcare.theclinics.com/article/S0749-0704(17)30006-4/fulltext|journal=Critical Care Clinics|language=en|volume=33|issue=2|pages=iii–v|doi=10.1016/S0749-0704(17)30006-4|doi-access=free}}</ref><ref name=":8">{{Cite web|url=https://www.va.gov/GRECC/Tennessee_Valley_GRECC.asp|title=Tennessee Valley GRECC - Geriatric Research Education and Clinical Centers|last1=Foley|first1=Tim|date=2010-03-30|website=U.S. Department of Veterans Affair|language=en|access-date=2017-09-29}}</ref><ref>{{Cite web |last1=Kumar |first1=Ajoy |last2=Gabbard |first2=Erika |last3=Smith |first3=Heidi AB |last4=Vedral-Baron |first4=Jennifer |last5=Aldrich |first5=Matt |last6=Ely |first6=E. Wesley |date=December 21, 2017 |title=ICU liberation: Optimizing quality and efficiency of critical care delivery |url=https://www.beckershospitalreview.com/quality/icu-liberation-optimizing-quality-and-efficiency-of-critical-care-delivery.html |access-date=2017-12-26 |website=Beckers Hospital Review |language=en-US}}</ref>


Ely's work is focused on [[Ageing|aging]], [[delirium]], post-ICU [[dementia]], and other disorders related to [[post-intensive care syndrome]], a set of conditions common especially in elderly patients that develops during acute care hospitalization and could be caused by the treatments used in [[intensive care medicine]].<ref name=":5">{{Cite news|url=https://www.theatlantic.com/health/archive/2015/06/the-overlooked-danger-of-delirium-in-hospitals/394829/|title=The Overlooked Danger of Delirium in Hospitals|last1=Boodman|first1=Sandra G.|work=The Atlantic|access-date=2017-09-21|language=en-US}}</ref><ref>{{Cite news|url=https://newoldage.blogs.nytimes.com/2011/11/02/another-hospital-hazard-for-the-elderly/|title=Another Hospital Hazard for the Elderly|last1=Seliger|first1=Susan|date=2011-11-02|work=The New York Times|access-date=2017-09-22|language=en}}</ref> The diagnosis and treatment protocols developed by Ely and his research group have been validated by independent studies, translated into many languages, and adopted by hospitals around the world.<ref>{{Cite news|url=https://www.welt.de/print/wams/wissen/article155359447/Intensive-Verwirrung.html|title=Intensive Verwirrung|last1=Nauber|first1=Teresa|date=2016-05-15|work=Die Welt|access-date=2017-09-21}}</ref><ref name=":11">{{Cite journal|last1=Gusmao-Flores|first1=Dimitri|last2=Salluh|first2=Jorge Ibrain Figueira|last3=Chalhub|first3=Ricardo Ávila|last4=Quarantini|first4=Lucas C|date=2012|title=The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies|journal=Critical Care|volume=16|issue=4|pages=R115|doi=10.1186/cc11407|pmc=3580690|pmid=22759376}}</ref>
Ely's work is focused on [[Ageing|aging]], [[delirium]], post-ICU [[dementia]], and other disorders related to [[post-intensive care syndrome]], a set of conditions common especially in elderly patients that develops during acute care hospitalization and could be caused by the treatments used in [[intensive care medicine]].<ref name=":5">{{Cite news|url=https://www.theatlantic.com/health/archive/2015/06/the-overlooked-danger-of-delirium-in-hospitals/394829/|title=The Overlooked Danger of Delirium in Hospitals|last1=Boodman|first1=Sandra G.|work=The Atlantic|access-date=2017-09-21|language=en-US}}</ref><ref>{{Cite news|url=https://newoldage.blogs.nytimes.com/2011/11/02/another-hospital-hazard-for-the-elderly/|title=Another Hospital Hazard for the Elderly|last1=Seliger|first1=Susan|date=2011-11-02|work=The New York Times|access-date=2017-09-22|language=en}}</ref> The diagnosis and treatment protocols developed by Ely and his research group have been validated by independent studies, translated into many languages, and adopted by hospitals around the world.<ref>{{Cite news|url=https://www.welt.de/print/wams/wissen/article155359447/Intensive-Verwirrung.html|title=Intensive Verwirrung|last1=Nauber|first1=Teresa|date=2016-05-15|work=Die Welt|access-date=2017-09-21}}</ref><ref name=":11">{{Cite journal|last1=Gusmao-Flores|first1=Dimitri|last2=Salluh|first2=Jorge Ibrain Figueira|last3=Chalhub|first3=Ricardo Ávila|last4=Quarantini|first4=Lucas C|date=2012|title=The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies|journal=Critical Care|volume=16|issue=4|pages=R115|doi=10.1186/cc11407|pmc=3580690|pmid=22759376}}</ref>

Revision as of 14:42, 27 May 2022

E. Wesley Ely
M.D., M.P.H.
EducationTulane University
School of Public Health
Tulane University Medicine
Employers
Known forICU delirium and post-ICU dementia research
Websitewww.icudelirium.org

Eugene Wesley Ely Jr. is an American physician, writer, and professor of medicine who serves as the Grant W. Liddle Endowed Chair at Vanderbilt University School of Medicine. He is conducting research as a geriatric intensivist in the Division of Pulmonary and Critical Care Medicine and the Center for Health Services Research at Vanderbilt University Medical Center. He is also the associate director of research at the Tennessee Valley Geriatric Research Education and Clinical Center (GRECC), part of the U.S. Department of Veterans Affairs.[1][2][3]

Ely's work is focused on aging, delirium, post-ICU dementia, and other disorders related to post-intensive care syndrome, a set of conditions common especially in elderly patients that develops during acute care hospitalization and could be caused by the treatments used in intensive care medicine.[4][5] The diagnosis and treatment protocols developed by Ely and his research group have been validated by independent studies, translated into many languages, and adopted by hospitals around the world.[6][7]

Early life and education

Ely attended Jesuit High School in Shreveport, Louisiana, where his mother Diana Lowe Ely was an English teacher and theater director of the high school.[8][9][10] His father Eugene Wesley Ely was a mechanical engineer who worked for Ingersoll-Rand.[11] After high school, Ely Jr. attended Tulane University in New Orleans, Louisiana, where he graduated summa cum laude with a bachelor's degree in Biology in 1985. He went on to attend the university's School of Public Health and Tropical Medicine, graduating with a public health master's degree in 1989. Ely earned his medical degree from the Tulane University School of Medicine later the same year.[12][13]

Career

After graduating from medical school, Ely began his residency at Bowman Gray School of Medicine (now known as Wake Forest School of Medicine). After three years as a resident, he continued at the hospital as a postdoctoral fellow until 1995.[13]

Until 1998, Ely served as professor of internal medicine at the same medical school and medical director of its Chronic Lung Failure Clinic. In 1998, Ely trained in lung transplantation at Barnes-Jewish Hospital of the Washington University School of Medicine in St. Louis, Missouri before leaving Bowman Gray to serve as a professor of medicine at Vanderbilt University Medical Center.[13] Since 1998, Ely has served as a pulmonologist, professor and researcher at Vanderbilt.[12][14][15]

His research is focused on the diagnosis, causes, and management of delirium and other cognitive disorders developed during a patient's hospital stay, especially in geriatric patients.[16][17] He founded and currently heads the ICU Delirium and Cognitive Impairment Study Group at Vanderbilt.[4][18] Ely's group has been studying the long term effects of mechanical ventilation and sedation on patients in intensive care units (ICU).[19] The group also publishes a website in an attempt to educate potential patients, families, doctors and other healthcare professionals about the effects and causes of delirium and post-intensive care syndrome (PICS).[20][21] Ely is one of several physicians that encourages a reduction in the use of sedatives (especially benzodiazepines) to shorten patients' time on mechanical ventilation during ICU treatment.[15] With others at Vanderbilt, the team also developed an outpatient post-ICU clinic for patients at Vanderbilt.[22] Ely was also a co-chair of the ICU Liberation Campaign of Society for Critical Care Medicine, which encourages the use of protocols to mitigate the effects of delirium and PICS.[15][23] Together with Pratik Pandharipande, Ely co-directs the Critical Illness, Brain Dysfunction and Survivorship Center (CIBS Center) at Vanderbilt University Medical Center.[24]

Research

In 1996, while serving as chief resident at Bowman Gray,[13] Ely and his colleagues published the findings of a study into the efficacy of a ventilator weaning protocol (called spontaneous breathing trials) in shortening the duration an ICU patient required assistance through mechanical ventilation as well as reducing complications and cost of care. The study published in The New England Journal of Medicine[25] reported that "daily screening followed by spontaneous breathing trials in medical and coronary intensive care units reduced the duration of ventilation from a median of 6.0 to 4.5 [days]."[26]

In 2001, Ely and Gordon Bernard were investigators on a study of the recombinant-form Activated Protein C (known as Drotrecogin alfa) and its possible efficacy in the treatment of sepsis.[27][28] The same year, Ely and his ICU Delirium Study Group developed CAM-ICU based on an earlier Confusion Assessment Method (CAM) developed by Sharon Inouye.[4][29] CAM-ICU is one of two commonly used methods to diagnose delirium in ICU patients.[7][30] It has been validated in later independent studies,[31] with a meta-analysis review of these studies showing high "pooled values for sensitivity and specificity of 80% and 95.9%, respectively."[7] Also in 2001, Ely was awarded The American Federation for Aging Research's Paul B. Beeson Career Development Award.[32] In 2002,[13] Ely was appointed Associate Director of Research at the Tennessee Valley Geriatric Research Education and Clinical Center (GRECC), part of the U.S. Department of Veterans Affairs.[1][2]

In a 2004 study, Ely et al. reported that delirium predicted an increased risk of mortality in ICU patients.[29][33] This has since been confirmed in at least two additional cohort studies.[29][34] In 2006, Ely was inducted into the American Society for Clinical Investigation for his work demonstrating how "delirium is associated with a tripling of the risk of death within 6 months of ICU" hospitalization.[35] In 2007, Ely, Pandharipande et al. published the results of the MENDS trial which investigated "the incidence and duration of delirium" when using the sedative dexmedetomidine compared to a benzodiazepine (specifically lorazepam).[30][36] This and subsequent studies have resulted "in the recommendation to minimize the use of benzodiazepines in the most recent sedation guidelines."[33]

In July 2007, Ely along with Timothy D. Girard and their colleagues presented the findings of a randomized clinical trial of a daily protocol of attempts at awakening the patient and allowing them to breathing independently. The 335-patient study presented at the International Conference of the American Thoracic Society reported that these daily tests, where the ICU patient was allowed to come out of sedation and breathe spontaneously without the use of a ventilator, resulted in the patients leaving the hospital an average of four days earlier.[37] In 2010, Ely and Girard reported a correlation between the length of time the patient was affected by delirium and their cognitive outcome in the long-term.[38][39][40] They developed a protocol named ABC which took earlier demonstrated attempts at ceasing sedation and paired it with concurrent attempts at a spontaneous breathing trial[37] through the ventilator weaning method developed by him in 1996.[26] Ely and his colleagues later extended the protocol, renamed ABCDEF Bundle, to include advice on the choice of sedation drugs, monitoring of delirium, early exercise,[15][41][42] and encouragement of family participation.[43]

In 2013, Ely was inducted into the Association of American Physicians.[44] In October 2013, Ely, Pandharipande, and their team published the results of a study, sponsored by the National Institutes of Health and the Department of Veterans Affairs, about the long-term effects of ICU Delirium.[45][46] The study reported that even after a one-year period, "34 percent of patients [affected by ICU Delirium] were still functioning on the same level as someone with moderate traumatic brain injury and 24 percent at the level of a person with mild Alzheimer's."[47]

In 2018, he reported to the annual congress of the European Society of Intensive Care Medicine the results of the MIND-USA study into the efficacy of haloperidol and ziprasidone in the treatment of delirium. The antipsychotic drugs used for decades for the treatment of ICU delirium were found to be ineffective for that purpose, according to the study by Ely and his colleagues published in the NEJM.[48][49][50][51]

During the COVID-19 pandemic, Ely et al. conducted the COVID-D study which documented the prevalence of coma and delirium occurring in ICU patients with COVID-19, driven by overuse of the sedatives and isolation from their family.[52][53] In another study, MENDS II, they noted the equivalence in clinical outcomes between the use of propofol and dexmedetomidine on mechanically ventilated adult patients with sepsis.[54] Ely and Vincent Marconi were the principal investigators of the COV-Barrier study that found a reduction in mortality in COVID-19 patients treated with baricitinib in addition to the standard treatment.[55][56][57]

Other writings

Ely writes reflective opinion pieces and editorials about his personal experiences as a physician, which have been published in the Annals of Internal Medicine, JAMA, and The Wall Street Journal, among other periodicals.[58] He participates in the ongoing debate on euthanasia and physician-assisted suicide through medical literature[59] and international debates.[60] He also wrote a CNN Opinion piece describing his own experiences with patients in palliative care who desired assisted suicide.[61][62]

In May 2019, Ely wrote an opinion article published in USA Today, arguing against "death by donation", a practice currently illegal in the U.S. and Canada where a patient voluntarily donates their organs while still alive, subsequently leading to their death.[63][64] In late June 2020, Ely wrote a Perspective article for The Washington Post describing the difficulties of treating COVID-19 patients while conducting ethical research into new treatment regimens for the disease and its effects including delirium.[65] In 2021, Ely wrote about his experience treating COVID-19 patients in The Lancet,[66] STAT,[67] The Daily Beast[68] and The Tennessean.[69]

Ely’s first book to a lay audience, Every Deep-Drawn Breath: A Critical Care Doctor on Healing, Recovery, and Transforming Medicine in the ICU, was published by Scribner in September 2021.[70] In the book, Ely reviews some of the things he has learned about intensive care medicine during his three decade career. In the form of narrative nonfiction, he recounts the stories of patients along with a historical review of the evolution of ICU care and the development of its medical innovations.[71][72] Ely describes how he implemented the ABCDEF guidelines, including maintaining a patient ICU diary for them to read once recovered and including family and friends in the treatment plan.[73] In a review for The Washington Post, Katie Hafner writes:

[Ely] depicts in brushstrokes broad and fine the horror that trails after many people once they leave the ICU[…] His central argument is this: the classic “sedate and immobilize” standard of care for ICU patients on ventilators should be discarded, and a patient-centered, comprehensive, evidence-based approach should be taken when treating all critically ill patients. Much of the book tells the stories of individual patients with PICS, each more wrenching than the last.[74]

Ely donated all proceeds from the book to the ICU patients and their family members.[73] Every Deep-Drawn Breath was one of the winners of the 2022 Christopher Award, which is given to films, TV programs and books with "stories of people who bring light into dark situations".[75]

Personal life

Ely has three daughters with his wife Kim Ely, who also works at Vanderbilt University Medical Center. She is a surgical pathologist who graduated from Massachusetts Institute of Technology and like her husband attended Tulane University School of Medicine.[12]

He is the president of the Nashville Guild of the Catholic Medical Association.[76]

Selected bibliography

Articles

Books

References

  1. ^ a b Napolitano, Lena M.; Kellum, John A., eds. (2017-04-01). "Contributors". Critical Care Clinics. 33 (2): iii–v. doi:10.1016/S0749-0704(17)30006-4.
  2. ^ a b Foley, Tim (2010-03-30). "Tennessee Valley GRECC - Geriatric Research Education and Clinical Centers". U.S. Department of Veterans Affair. Retrieved 2017-09-29.
  3. ^ Kumar, Ajoy; Gabbard, Erika; Smith, Heidi AB; Vedral-Baron, Jennifer; Aldrich, Matt; Ely, E. Wesley (December 21, 2017). "ICU liberation: Optimizing quality and efficiency of critical care delivery". Beckers Hospital Review. Retrieved 2017-12-26.
  4. ^ a b c Boodman, Sandra G. "The Overlooked Danger of Delirium in Hospitals". The Atlantic. Retrieved 2017-09-21.
  5. ^ Seliger, Susan (2011-11-02). "Another Hospital Hazard for the Elderly". The New York Times. Retrieved 2017-09-22.
  6. ^ Nauber, Teresa (2016-05-15). "Intensive Verwirrung". Die Welt. Retrieved 2017-09-21.
  7. ^ a b c Gusmao-Flores, Dimitri; Salluh, Jorge Ibrain Figueira; Chalhub, Ricardo Ávila; Quarantini, Lucas C (2012). "The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies". Critical Care. 16 (4): R115. doi:10.1186/cc11407. PMC 3580690. PMID 22759376.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  8. ^ "Editorial Board". Catholic Medical Association. Retrieved 2017-09-29.
  9. ^ "Ann Lowe's Obituary on Shreveport Times". Shreveport Times. 2010-04-24. Retrieved 2017-10-18.
  10. ^ "Noel Ranney's Obituary on Shreveport Times". Shreveport Times. Retrieved 2017-10-18.
  11. ^ "Eugene Wesley Ely's Obituary on Houston Chronicle". Houston Chronicle. 2007-04-10. Retrieved 2017-10-14 – via Legacy.com.
  12. ^ a b c "Allergy Pulmonary Faculty: Ely, E. Wesley, MD, MPH". Vanderbilt University Medical Center. 2016. Retrieved 2017-09-11.
  13. ^ a b c d e "Curriculum Vitae" (PDF). World Congress of Internal Medicine. 2016-03-28. Retrieved 2017-09-10.
  14. ^ "Eugene Wesley Ely". Faculty Profiles. Vanderbilt University. Retrieved 25 May 2016.
  15. ^ a b c d McFarling, Usha Lee (2016-10-14). "Hospitals struggle to address terrifying 'ICU delirium'". STAT. Retrieved 2017-09-22.
  16. ^ Petersen, Kaitlin (January 2010). "Mind Matters". North Shore Magazine.
  17. ^ Arumugam, Suresh; et al. (2017). "Delirium in the Intensive Care Unit". Journal of Emergencies, Trauma, and Shock. 10 (1): 37–46. doi:10.4103/0974-2700.199520. PMC 5316795. PMID 28243012.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  18. ^ Fellows, Jacqueline (2011-02-25). "Most ICU Patients Return Home With Brain Injury". Nashville Public Radio. Retrieved 2017-09-22.
  19. ^ Baldauf, Sarah (2007-07-15). "How to Recognize Signs of Delirium in the Hospital". U.S. News & World Report. Retrieved 2017-09-21.
  20. ^ Ritacca, Frank V. (2004-02-17). "ICUDelirium.org". Critical Care. 8 (4): 296. doi:10.1186/cc2826. PMC 4082220.
  21. ^ Landro, Laura (2007-10-17). "Hospitals Combat an Insidious Complication". Wall Street Journal. Retrieved 2017-09-21.
  22. ^ Lamas, Daniela J. (2013-04-08). "Delirium-induced flashbacks plague many former ICU patients". The Boston Globe. Retrieved 2017-09-22.
  23. ^ Silverman, Lauren (2017-02-22). "With Fewer Meds, More Movement, Parkland Hospital Fights 'Delirium' Among ICU Patients". KERA News. Retrieved 2017-09-22.
  24. ^ Humphrey, Nancy (2018-10-04). "New center formed to treat, study ICU delirium, dementia". Vanderbilt University. Retrieved 2019-01-26.
  25. ^ Luce, John M. (1996-12-19). "Reducing the Use of Mechanical Ventilation". New England Journal of Medicine. 335 (25): 1916–1917. doi:10.1056/NEJM199612193352509. PMID 8948568.
  26. ^ a b Dembinski, Rolf; Kuhlen, Ralf (2015-02-16). "Weaning: Protocols vs clinically driven". In Moreno, Rui P.; Rhodes, Andrew; Kuhlen, Ralf; Ranieri, Marco (eds.). Controversies in Intensive Care Medicine. MWV. pp. 11–13. ISBN 9783954661916.
  27. ^ Matthay, Michael A. (2009-08-20). "Severe Sepsis — A New Treatment with Both Anticoagulant and Antiinflammatory Properties". New England Journal of Medicine. 344 (10): 759–762. doi:10.1056/nejm200103083441009. PMID 11236781.
  28. ^ Ranieri, V. Marco; Thompson, B. Taylor; Barie, Philip S.; Dhainaut, Jean-François; Douglas, Ivor S.; Finfer, Simon; Gårdlund, Bengt; Marshall, John C.; Rhodes, Andrew (2012-05-31). "Drotrecogin alfa (activated) in adults with septic shock". The New England Journal of Medicine. 366 (22): 2055–2064. doi:10.1056/NEJMoa1202290. ISSN 1533-4406. PMID 22616830.
  29. ^ a b c Lin, Shu-Min; et al. (December 2004). "The impact of delirium on the survival of mechanically ventilated patients*". Critical Care Medicine. 32 (11): 2254–2259. doi:10.1097/01.ccm.0000145587.16421.bb. PMID 15640638. S2CID 29831112.
  30. ^ a b Arumugam, Suresh; El-Menyar, Ayman; Al-Hassani, Ammar; Strandvik, Gustav; Asim, Mohammad; Mekkodithal, Ahammed; Mudali, Insolvisagan; Al-Thani, Hassan (2017). "Delirium in the Intensive Care Unit". Journal of Emergencies, Trauma, and Shock. 10 (1): 37–46. doi:10.4103/0974-2700.199520. PMC 5316795. PMID 28243012.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  31. ^ Bruno, Jeffrey J.; Warren, Mary Lou (2010-06-29). "Intensive Care Unit Delirium". In Simmons, Debora (ed.). Safety, An Issue of Critical Care Nursing Clinics. Elsevier Health Sciences. pp. 25–44. ISBN 978-1455700226.
  32. ^ "Beeson Annual Report" (PDF). American Federation for Aging Research. 2011. Retrieved 2017-09-21.
  33. ^ a b Burry, Lisa; Rose, Louise; McCullagh, Iain J.; Fergusson, Dean A.; Ferguson, Niall D.; Mehta, Sangeeta (2014-07-09). "Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation". The Cochrane Database of Systematic Reviews. 2018 (7): CD009176. doi:10.1002/14651858.CD009176.pub2. PMC 6517142. PMID 25005604.
  34. ^ Ouimet, Sébastien; et al. (2007-01-01). "Incidence, risk factors and consequences of ICU delirium". Intensive Care Medicine. 33 (1): 66–73. doi:10.1007/s00134-006-0399-8. PMID 17102966. S2CID 12806750.
  35. ^ "Member directory: E. Wesley Ely, MD, MPH". American Society for Clinical Investigation. Retrieved 2017-09-21.
  36. ^ Lonergan, Edmund; Luxenberg, Jay; Areosa Sastre, Almudena (2009-10-07). "Benzodiazepines for delirium". The Cochrane Database of Systematic Reviews (4): CD006379. doi:10.1002/14651858.CD006379.pub3. PMC 6669269. PMID 19821364.
  37. ^ a b Finn, Robert (July 2007). "'Wake Up and Breathe' Improved ICU Outcomes" (PDF). Chest Physician. 2 (7): 1, 9. Archived from the original (PDF) on 2017-08-08 – via ICU Delirium and Cognitive Impairment Study Group's website.
  38. ^ Aldhous, Peter (2011-07-27). "Delirium in hospital can be a killer for the elderly". New Scientist. Retrieved 2017-09-22.
  39. ^ Kuehn, Bridget M. (2010-07-28). "Delirium Often Not Recognized or Treated Despite Serious Long-term Consequences". JAMA. 304 (4): 389–90, 395. doi:10.1001/jama.2010.965. PMID 20664031.
  40. ^ Miller, Kenneth (2017-01-10). "Special Report: After the ICU". Prevention. p. 89. Retrieved 2017-09-21 – via ICUDelirium.org.
  41. ^ Balas, Michele C.; et al. (May 2014). "Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility (ABCDE) Bundle". Critical Care Medicine. 42 (5): 1024–1036. doi:10.1097/CCM.0000000000000129. PMC 4105208. PMID 24394627.
  42. ^ Landro, Laura (2011-02-15). "Changing Intensive Care to Improve Life Afterward". The Wall Street Journal. Retrieved 2017-09-22.
  43. ^ Seliger, Susan (2011-11-11). "Preventing Hospital Delirium". The New York Times. Retrieved 2017-09-22.
  44. ^ "Eugene (Wes) Ely". American Association of Physicians. 2013. Retrieved 2017-09-28.
  45. ^ Wilemon, Tom (2013-10-02). "Study: Extended ICU stays cause brain damage". USA Today. Retrieved 2017-10-13.
  46. ^ Herridge, Margaret; Cameron, Jill I. (2013-10-03). "Disability after Critical Illness". New England Journal of Medicine. 369 (14): 1367–1369. doi:10.1056/NEJMe1309482. ISSN 0028-4793. PMID 24088098.
  47. ^ Emery, Gene (2013-10-03). "Brain problems can linger months after ICU stay". Reuters. Retrieved 2017-10-13.
  48. ^ Bleck, Thomas P. (2018-12-27). "Dopamine Antagonists in ICU Delirium". New England Journal of Medicine. 379 (26): 2569–2570. doi:10.1056/NEJMe1813382. ISSN 0028-4793. PMID 30346241. S2CID 53043161.
  49. ^ Harris, Richard (October 22, 2018). "Antipsychotic Drugs Don't Ease ICU Delirium". NPR. Retrieved 2019-01-26.
  50. ^ Evans, Melanie (2018-10-22). "No Benefit Seen From Antipsychotics Used in Delirious Hospital Patients". The Wall Street Journal. ISSN 0099-9660. Retrieved 2019-01-26.
  51. ^ Monaco, Kristen (2018-10-22). "Antipsychotics Flop in ICU Delirium Trial". Medpage Today. Retrieved 2019-01-26.
  52. ^ Long, Brit; Carius, Brandon M.; Chavez, Summer; Liang, Stephen Y.; Brady, William J.; Koyfman, Alex; Gottlieb, Michael (April 2022). "Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation". The American Journal of Emergency Medicine. 54: 46–57. doi:10.1016/j.ajem.2022.01.028. PMC 8779861. PMID 35121478.
  53. ^ George, Judy (2021-01-11). "Acute Brain Dysfunction Prolonged in COVID-19 ICU Patients". MedPage Today. Retrieved 2022-04-25.
  54. ^ Wang, Caimu; Chen, Qijiang; Wang, Ping; Jin, Weisheng; Zhong, Chao; Ge, Zisheng; Xu, Kangmin (2021-12-13). "The Effect of Dexmedetomidine as a Sedative Agent for Mechanically Ventilated Patients With Sepsis: A Systematic Review and Meta-Analysis". Frontiers in Medicine. 8: 776882. doi:10.3389/fmed.2021.776882. ISSN 2296-858X. PMC 8711777. PMID 34966760.
  55. ^ Menéndez, J. Carlos (2022-01-20). "Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective". Molecules. 27 (3): 658. doi:10.3390/molecules27030658. ISSN 1420-3049. PMC 8838458. PMID 35163923.
  56. ^ "Lilly and Incyte announce results from the Phase 3 COV-BARRIER study of baricitinib in hospitalized COVID-19 patients | Eli Lilly and Company". Lilly. April 8, 2021. Retrieved 2022-04-25.
  57. ^ Elahi, Reza; Karami, Parsa; Heidary, Amir Hossein; Esmaeilzadeh, Abdolreza (April 2022). "An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)". International Immunopharmacology. 105: 108536. doi:10.1016/j.intimp.2022.108536. PMC 8747952. PMID 35074571.
  58. ^ Guernsey, Diane, ed. (2015-07-24). "Last Stand: About the author". Pulse: Voices from the Heart of Medicine. Archived from the original on 2019-11-14. Retrieved 2017-09-29.
  59. ^ Goligher, Ewan C.; Ely, E. Wesley; et al. (February 2017). "Physician-Assisted Suicide and Euthanasia in the ICU: A Dialogue on Core Ethical Issues*". Critical Care Medicine. 45 (2): 149–155. doi:10.1097/CCM.0000000000001818. ISSN 0090-3493. PMC 5245170. PMID 28098622.
  60. ^ Critical Care (2017-02-01), Critical Connections Live: Physician-Assisted Suicide and Euthanasia in the ICU, retrieved 2018-03-31
  61. ^ Ely, E. Wes. "What happens when a patient says, 'Doc, help me die'". CNN. Retrieved 2018-03-31.
  62. ^ Woods, Jim (2019-01-15). "Second lawsuit filed alleging deadly dosage of fentanyl by Mount Carmel doctor". The Columbus Dispatch. Retrieved 2019-01-26.
  63. ^ Ely, E. Wesley (May 2, 2019). "Death by organ donation: Euthanizing patients for their organs gains frightening traction". USA Today. Retrieved 2019-08-05.
  64. ^ Cook, Michael (May 5, 2019). "BioEdge: Pressure building to abolish the dead donor rule". BioEdge. Retrieved 2019-08-05.
  65. ^ Ely, E. Wesley (June 30, 2020). "Treating coronavirus is brutal. But our hunt for better medicine keeps us going". The Washington Post. Retrieved July 2, 2020.
  66. ^ Ely, E Wesley (March 2021). "Each person is a world in COVID-19". The Lancet Respiratory Medicine. 9 (3): 236–237. doi:10.1016/S2213-2600(21)00027-8. PMID 33493443. S2CID 231689773.
  67. ^ Ely, E. Wesley (2021-10-22). "Don't give Covid-19 long-haulers the silent treatment". STAT. Retrieved 2022-04-28.
  68. ^ Ely, E. Wesley (2021-10-10). "What You Need to Know Before You Wind Up in the ICU". The Daily Beast. Retrieved 2022-04-28.
  69. ^ Ely, Wes (2021-09-14). "How freeing a shackled prisoner sick from COVID-19 liberated me as a physician | Opinion". The Tennessean. Retrieved 2022-04-28.
  70. ^ "Nonfiction Book Review: Every Deep-Drawn Breath: A Critical Care Doctor on Healing, Recovery, and Transforming Medicine in the ICU by Wes Ely". www.pubishersweekly.com. 2021-07-21. Retrieved 2022-04-28.
  71. ^ "Every Deep-Drawn Breath". Kirkus. 2021-09-07.
  72. ^ Boucher, Makenzie (2021-10-15). "'It is about rehumanizing medicine,' author of 'Every Deep-Drawn Breath' visits Shreveport". The Times. Retrieved 2022-04-28.
  73. ^ a b O'Connor, Aine (November 2021). "Every deep-drawn breath". The Lancet Respiratory Medicine. 9 (11): 1218. doi:10.1016/S2213-2600(21)00372-6. S2CID 239084303.
  74. ^ Hafner, Katie (2021-10-29). "A stay in the ICU can be terrifying. It might not get better after release". The Washington Post. ISSN 0190-8286. Retrieved 2022-04-28.
  75. ^ "The Christophers Awards Announced". thechristophers. Retrieved 2022-04-28.
  76. ^ Ely, EW (2016-04-02). Williams, William V. (ed.). "E. Wesley Ely: Bibliographical Note". The Linacre Quarterly. 83 (2): 150–156. doi:10.1080/00243639.2016.1163938. PMC 5102211. PMID 27833193.
Retrieved from "https://en.wikipedia.org/w/index.php?title=E._Wesley_Ely&oldid=1090121701"