Talk:Lurasidone

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lurasidone hydrochloride as enantiospcefic isomer —Preceding unsigned comment added by 220.225.147.89 (talk) 16:16, 25 March 2011 (UTC)

That's not very specific. Which one? David Spector (talk) 22:47, 8 March 2014 (UTC)

negative symptoms

The history of nearly every atypical antipsychotic that is introduced dictates that at the introduction of the new atypical, claims are initially made to suggest the drug treats negative symptoms of schizophrenia. Only later is it realized that this is not the case, and subsequent studies rule this not to be so. Case in point: Abilify. Everyone thought that would treat negative symptoms, and it hasn't.

I'm trying to remain open-minded, however, and if someone can provide clinical trials demonstrating signifigant changes in, say, negative symptoms on the PAANS scale, then please note this in the message body of your edit, along with the citation-- which should link directly to the section in which negative symptoms are reduced. However, the clinical trials I've read demonstrate no efficacy of lurasidone for negative symptoms. The only drug presently in research for negative symptoms of much promise, it seems-- glycine-like agents aside- is Shire's Vyvanse, which is in Phase II trials for cogntive dysfunction and negative symptoms in negative symptom predominant schizophrenia.Fair objective (talk) 19:33, 1 March 2012 (UTC)

I just uploaded a systematic review by the SMC of NHS Scotland that has shown reductions of positive and negative scores on the PANSS over 12 months. Here is the citation and pdf: Scottish Medicines Consortium. (2014). lurasidone, 18.5mg, 37mg, 74mg film-coated tablets (Latuda ® ) SMC No. (994/14) Sunovion 05. NHS Scotland, (October), 1–12. http://www.scottishmedicines.org.uk/files/advice/lurasidone__Latuda__FINAL_Sept_2014_amended_15.09.14_for_website.pdf It is also important to note that their findings suggest that Lurasidone was most effective and practical when used as an alternative after failed use of other atypical antipsychotics such as aripiprazole. Zharris24 (talk) 00:07, 8 March 2016 (UTC)

Withdrawal Symptoms

Until we can get a reliable source for specific withdrawal symptoms of this drug, I might just go ahead and delete this section. Feel free to revert if I'm wrong.

MissRainbowDash (talk) 14:54, 23 November 2012 (UTC)

This is well known at this point in time that Latuda does cause withdrawals. If you’re not listing withdrawals you are missing facts. I am one of those people experiencing withdrawals or what I call brain damage from a botched “taper” by a doctor. Yes, a doctor permanently injured me. You all have no clue what this drug does and all you have is 6 weeks trials and nothing long term or on withdrawals specifically. Also, the hashtags on #latudawithdrawal is now at 19.8k on TikTok. So that’s something. https://www.drugs.com/medical-answers/you-stop-taking-latuda-immediately-3547539/#:~:text=If%20you%20stop%20taking%20Latuda,get%20emergency%20help%20right%20away. Lady Meg (talk) 12:40, 4 December 2023 (UTC)

History in Japan

This drug was developed by a Japanese pharmaceutical company, yet there is no mention of its approval/usage in Japan. I think this should be rectified, but I don't know enough on the subject to do so. Can someone with Japanese language experience research this? Based on my rudimentary knowledge of kanji (from Chinese), I think the Japanese article says it was approved in 2009 in Japan (2009年現在...) Quodfui (talk) 11:51, 2 April 2014 (UTC)

While I can't read Japanese, I will add a notice to the top of the article. 76.100.136.246 (talk) 21:31, 22 September 2015 (UTC)

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Akathisia

I see that we’ve just put “movement disorders” instead of AKATHISIA. Unless you’re a Pharma rep, AKATHISIA needs to be stated. It’s one of the TOP side effects. Akathisia isn’t survivable for a lot of people and they don’t even know they have it. Doctors fail to recognize it and it’s usually seen as mental health getting “worse” or it’s misdiagnosed as “anxiety”. If AKATHISIA isn’t mentioned anywhere in this article, you’re doing patients a huge disservice. Lady Meg (talk) 11:22, 4 December 2023 (UTC)