User talk:Xasodfuih

specific delusions schizophrenia

Hi Xasodfuih,

how long does the question of synthesised sources tag have to be on: http://en.wikipedia.org/wiki/Causes_of_schizophrenia#Development_of_specific_delusions

I don't think there are any synthesised ideas.

Notpayingthepsychiatrist (talk) 08:33, 8 March 2009 (UTC) (forgot to log in).

I think the entire section is a bit off-topic in that article. I posted a notice about the merge proposal on WT:MED. Hopefully that will get more editors involved so consensus can be formed. Xasodfuih (talk) 12:23, 8 March 2009 (UTC)

Thanks for help

Hi Xasodfuih,

thanks for the help. I've rewritten Retinal's lede—a new word for me—and moved the scariest stuff out of it. Wikipedia provides abundant evidence that good ledes are hard to write. J G Campbell (talk) 20:40, 9 March 2009 (UTC)

Paracetamol

Hi there

You mentioned some difficulties in describing the industrial synthesis of this compound. Would you like me to help? Perhaps you can tell me where you found your info? --Rifleman 82 (talk) 16:39, 10 March 2009 (UTC)

Thanks for the offer. I'm not ignoring you, but I need to get the book again (returned it); it was in (Sittig's 3rd ed. p. 47); paracetamol synthesis was not in Ullmann's last time I checked. Xasodfuih (talk) 07:12, 11 March 2009 (UTC)

I found the book at my local library. You're saying page 47 of 3rd ed? It'll take a while, but I'll go get it. I'll let you know when I do. --Rifleman 82 (talk) 02:19, 12 March 2009 (UTC)

Negative air ionization therapy

Note your work at the above page. Please note there is also study at Portsmouth Council UK. Please note existence of page Air ioniser also. I'd welcome your thoughts about improvement of the subject's treatment, linking etc. Thanks. Redheylin (talk) 02:02, 12 March 2009 (UTC)

I'm not aware of the study in Portsmouth that you mentioned above. Negative air ionization therapy mentions all studies I was able to find in pubmed. The Columbia faculty that did the two RCTs on SAD made it pretty clear that commercially available stuff don't produce enough ions; whether he's just saying this because he might be involved in patenting new stuff, I don't know—it happens at times in academia. For now I don't see a reason to merge the two articles, and they are already linked to each other. Xasodfuih (talk) 10:59, 12 March 2009 (UTC)

Seen this?[1] I also think there is no need to merge, but there is a need to co-ordinate and link to comp med subjects. The Leeds study is a better replication of the Portsmouth experiment, which was not controlled. Point is; there may be benefits from air-purification and better oxygen uptake that go beyond SAD. Redheylin (talk) 04:29, 14 March 2009 (UTC)

Please note use of conventional commercial ionisers. Redheylin (talk) 04:32, 14 March 2009 (UTC)

What density/flow of ions works for SAD and what works for killing bacteria may be very different. Unless you have numbers to show they are the same, I don't see why this the Portsmouth study on pathogen needs to be mentioned in negative air ionization therapy. Xasodfuih (talk) 16:52, 14 March 2009 (UTC)

FYI: there's another paper (not clear if it's reporting the same study) from more or less the same group on the bactericidal mechanism of action here. Xasodfuih (talk) 16:59, 14 March 2009 (UTC)

Well. the paper you cited last (thanks) has the data

All the ion exposure experiments were undertaken under ambient room conditions. All seven bacterial species were exposed to negative air ions (with an electrode potential of -10 kV) for periods of 5, 10 and 15 minutes, with five replicates taken on each occasion. The process was then repeated for samples exposed to positive ions, with an electrode potential of +10 kV.

-Would you say that the phrase "Negative air ionization therapy" refers ONLY to SAD treatments? This is not clear in either article. I'd say that the mechanism HAS to be different, which makes me wonder whether any studies reflect upon the generalities of ionisation and the healthy environment, and how such general reflections should be incorporated.

For somewhat different reasons I'd draw your attention to Ionized bracelet. Also we have two different spellings of ionis/ze and no redirects. Do you want to take care of this?Redheylin (talk) 20:14, 14 March 2009 (UTC)

"Would you say that the phrase "Negative air ionization therapy" refers ONLY to SAD treatments?" Bactericidal action in the air is not therapy; it's not referred as such by the authors anyway. Also, there's no easy way to calculate the ion flow or density from the voltage (at least I don't know how to do it). As for ionized bracelet, that is clearly pseudoscience and unrelated as the effect on the air is negligible. Xasodfuih (talk) 21:20, 14 March 2009 (UTC)

pseudoscience - yes, I thought you ought to know. The density of ion flow would depend upon a measurement outside the ioniser practically, though no doubt tricks can be done with the inverse square law, since air-flow matters. What it shakes down to is; what kind of measure is given in the SAD studies? (*negative air ionization at high flow rate (93 minutes, 4.5x1014 ions/second); or 5) ionization at low flow rate (93 minutes, 1.7x1011 ions/second*) I take your point re. use of the word "therapy", though I'd not swear it's not been associated with domestic units. There may be room for a little cross-clarification here. Redheylin (talk) 23:13, 14 March 2009 (UTC)

Hum I see the problem** For a start the times are an order bigger, then they do not say how they calculated. But they do say it would be hard to get the same rate from an ordinary device. Have to stick it up your nose, I suppose. Do you want positively to avoid comparisons with other claimed health benefits? Is this "subjective feeling of summer" the only mechanism? Redheylin (talk) 23:23, 14 March 2009 (UTC)

New FAC/FAR delegates

Since you are the one who broached the subject, see the discussion here. Raul654 (talk) 20:38, 12 March 2009 (UTC)

Hard and soft drugs

Please undo this redirect and discuss it. There is an active discussion on improving the article on the talk page, and your redirect goes against a deletion discussion that was had in December. The article needs improving (a lot), but I don't agree with a redirect. The topic is notable, even if the current content is not encyclopedic. The concepts of hard and soft drugs exist outside of Dutch law. Thanks. Fences and windows (talk) 19:37, 14 March 2009 (UTC)

You can undo it yourself if you disagree. Better: replace the content with (1) sourced definitions for hard/soft (not WP:OR as they were before I redirected), and (2) examples given in context, i.e. not WP:SYNT. Xasodfuih (talk) 21:11, 14 March 2009 (UTC)

From Talk:Major depressive disorder...

Hi Xasodfuih, I just wanted to let you know that I felt very uncomfortable with the tone of some of your comments toward me, e.g. "(hint:..." and "...take that discussion there". These are somewhat condescending, at least in context and the way that I read them, and seemed unnecessarily harsh. Perhaps that was not your intention, and if that's the case then there's no problem. I just thought you should know how this was perceived by me. --Scray (talk) 07:21, 15 March 2009 (UTC)

I assure you it wasn't meant to be disrespectful, just expedient in order to keep the discussion focused. If you are disputing a guideline, such as the recommended use of metaanalyses by WP:MEDRS, you should really take the discussion to the guideline's talk page. Compared to your friend OM calling me an idiot and CAM POV pusher, I think I was quite restrained. Xasodfuih (talk) 07:32, 15 March 2009 (UTC)

I don't dispute the guideline. I dispute giving any tool undue weight; the use of any tool, no matter how good a tool, can result in poor results. It is unwise to simply accept all meta-analysis as revealed truth - and that is exactly why I used the word simply in my original statement - that meta-analyses are not simply the best form of evidence. This is not a dispute regarding a guideline, which is why I found your dismissal so off-putting. Evaluating literature involves more than naming the methods used. --Scray (talk) 16:02, 15 March 2009 (UTC)

I misunderstood your objection then. Am all for carefully reading what studies a metaanalysis included, what caveats they gave in their discussion section, what criticism they received in other publications etc. Most of the meaningful discussion on the article's talk page was actually centred around these issues. Xasodfuih (talk) 16:11, 15 March 2009 (UTC)

Also, if you think I'm pushing Omega3's, see Talk:Schizophrenia/Archive_4#Omega_3.27s where I excluded a review because I thought it was biased towards Omega3's, and my edits there on that issue, which resulted in the current text: "A 2003 review of four randomized controlled trials of EPA (an omega-3 fatty acid) vs. placebo as adjunctive treatment for schizophrenia found that two of the trials detected a significant improvement on positive and negative symptoms, and suggested that EPA may be an effective adjunct to antipsychotics.[119] The most recent meta-analysis (2006) failed however to find a significant effect.[120] A 2007 review found that studies of omega-3 fatty acids in schizophrenia, despite being mostly of high quality, have produced inconsistent results and small effect sizes of doubtful clinical significance.[121]" The last two sources are the same I used in the MDD article, but they do have a different conclusion for MDD. Xasodfuih (talk) 07:54, 15 March 2009 (UTC)