Talk:Long QT syndrome

Drugs causing prolonged QT interval

This list starting the LQTS page would in my opinion be better suited in a separate article, especially since the list should be much longer when updated. In stead there should be an appropiate link to the list in the aquired LQTS section

Genetic Testing

Genetic testing was discussed in JAMA on 21 Dec 05[1]. JFW | T@lk 21:55, 22 December 2005 (UTC)

Side effect of anti-psychotics

Side effect of anti-psychotics based on PI sheets for Haldol and Geodon. John Elder 02:17, 28 March 2006 (UTC)

LQT2 Section, Grammar

in the article http://en.wikipedia.org/wiki/Long_QT_syndrome, 
              should the txt under LQT2, "are poised so drug binding to them 
              will", be "drugs" or some gramatical change?

I changed this to "a drug". 6/18/08

Left Cardiac Sympathetic Denervation

Left Cardiac Sympathetic Denervation is absent from the article.   — C M B J   22:44, 17 December 2008 (UTC)

Non-genetic causes

I have removed a long list (unsourced) with conditions and states in which the QTc interval may be prolonged. They don't belong in this article, because they are not "syndromal". They need to be discussed in another article, either about QTc prolongation or TDP.

More common than the various congenital causes of long QT syndrome are acquired causes. They can be divided into two main categories - those due to disturbances in blood electrolytes and those due to various drugs:

• electrolyte disorders
  • hypokalemia
  • hypomagnesemia
  • hypocalcemia
• drug-induced
  • Antiarrhythmic drugs
    • Quinidine
    • Amiodarone
    • Sotalol
    • Procainamide
    • Ranolazine
  • Antihistamines
    • terfenadine
    • astemizole
  • Antibiotics
    • Macrolide
      • Erythromycin
    • Certain Fluoroquinolone antibiotics
      • Moxifloxacin
  • Major tranquilizers (i.e. antipsychotics)
    • Chlorpromazine
    • Haloperidol
  • Tricyclic antidepressants
  • Gastrointestinal Motility agents
    • Cisapride
    • Domperidone
  • Antipsychotic drugs
    • Haloperidol
    • Quetiapine
    • Thioridazine
    • Droperidol
  • Analgesics
    • Methadone
    • LAAM

Just as with the congenital causes of the Long QT syndrome, the acquired causes may also lead to the potentially lethal arrythmia known as Torsade de Pointes. Treatment is straightforward - replace any deficient electrolytes if present and stop any culprit drugs if the patient is using one (or more).

Given its relatively high frequency of use, its tendency for drug-drug interaction, and its inherent ability to prolong the QT interval, the macrolide antibiotic erythromycin is probably the most prevalent cause of acquired long QT syndrome. Indeed, use of erythromycin is associated with a rate of death more than double that of use of other antibiotics

In addition to the two major categories listed above, it should be noted that there are also some miscellaneous causes of QT prolongation such as anorexia nervosa, hypothyroidism, HIV infection, and myocardial infarction.

Hope this is OK. JFW | T@lk 14:59, 14 February 2010 (UTC)

QT interval sounds like the right place. JFW | T@lk 15:15, 14 February 2010 (UTC)

NEJM 2008

NEJM covered this in 2008 doi:10.1056/NEJMcp0706513 JFW | T@lk 12:53, 6 March 2011 (UTC)

Comparison Picture

could there be added a comparison picture of what a LQT looks like —Preceding unsigned comment added by 71.112.216.33 (talk) 17:08, 23 March 2011 (UTC)

treatment

What about using primidone as a treatment. It is mentioned in the primidone article that it has been used for this purpose.

AriaNo11 (talk) 18:11, 28 April 2011 (UTC)

Have a source for that? JFW | T@lk 20:18, 28 April 2011 (UTC)

Potassium supplementation as a treatment - *no* evidence?

It states that the use of potassium as a potential treatment is not evidence-based - I can understand this, but doesn't reference even an anecdotal reports of long QT going into remission after potassium supplementation, and/or in vitro studies of the effect of K supplementation on the functions of the various ion channels. I find it hard to believe there isn't *any* evidence whatsoever.