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<!-- Prevention and treatment -->
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Prevention is by [[Sexual abstinence|not having sex]], the use of [[condom]]s, or having sex with only one other person, who is not infected.<ref name=CDCFact2016/> Chlamydia can be cured by [[antibiotic]]s with typically either [[azithromycin]] or [[doxycycline]] being used.<ref name=CDC2015/> [[Erythromycin]] or azithromycin is recommended in babies and during [[pregnancy]].<ref name=CDC2015/> Sexual partners should also be treated and the infected people advised not to have sex for seven days and until symptom free.<ref name=CDC2015/> [[Gonorrhea]], [[syphilis]], and [[HIV/AIDS|HIV]] should be tested for in those who have been infected.<ref name=CDC2015/> Following treatment people should be tested again after three months.<ref name=CDC2015/>
Prevention is by [[Sexual abstinence|not having sex]], the use of [[condom]]s, or having sex only with persons who are not infected.<ref name=CDCFact2016/> Chlamydia can be cured by [[antibiotic]]s with typically either [[azithromycin]] or [[doxycycline]] being used.<ref name=CDC2015/> [[Erythromycin]] or azithromycin is recommended in babies and during [[pregnancy]].<ref name=CDC2015/> Sexual partners should also be treated and the infected people advised not to have sex for seven days and until symptom free.<ref name=CDC2015/> [[Gonorrhea]], [[syphilis]], and [[HIV/AIDS|HIV]] should be tested for in those who have been infected.<ref name=CDC2015/> Following treatment people should be tested again after three months.<ref name=CDC2015/>


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Revision as of 03:55, 5 October 2020

For other uses, see Chlamydia (disambiguation).

Chlamydia
Other namesChlamydia infection
Pap smear showing C. trachomatis (H&E stain)
Pronunciation
SpecialtyInfectious disease, gynecology, urology
SymptomsNone, vaginal discharge, discharge from the penis, burning with urination[1]
ComplicationsPain in the testicles, pelvic inflammatory disease, infertility, ectopic pregnancy[1][2]
Usual onsetFew weeks following exposure[1]
CausesChlamydia trachomatis spread by sexual intercourse or childbirth[3]
Diagnostic methodUrine or swab of the cervix, vagina, or urethra[2]
PreventionNot having sex, condoms, sex with only one non–infected person[1]
TreatmentAntibiotics (azithromycin or doxycycline)[2]
Frequency4.2% (women), 2.7% (men)[4][5]
Deaths~200 (2015)[6]

Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis.[3] Most people who are infected have no symptoms.[1] When symptoms do appear it can be several weeks after infection.[1] Symptoms in women may include vaginal discharge or burning with urination.[1] Symptoms in men may include discharge from the penis, burning with urination, or pain and swelling of one or both testicles.[1] The infection can spread to the upper genital tract in women, causing pelvic inflammatory disease, which may result in future infertility or ectopic pregnancy.[2] Repeated infections of the eyes that go without treatment can result in trachoma, a common cause of blindness in the developing world.[7]

Chlamydia can be spread during vaginal, anal, or oral sex, and can be passed from an infected mother to her baby during childbirth.[1] The eye infections may also be spread by personal contact, flies, and contaminated towels in areas with poor sanitation.[7] Chlamydia trachomatis only occurs in humans.[8] Diagnosis is often by screening which is recommended yearly in sexually active women under the age of twenty-five, others at higher risk, and at the first prenatal visit.[1][2] Testing can be done on the urine or a swab of the cervix, vagina, or urethra.[2] Rectal or mouth swabs are required to diagnose infections in those areas.[2]

Prevention is by not having sex, the use of condoms, or having sex only with persons who are not infected.[1] Chlamydia can be cured by antibiotics with typically either azithromycin or doxycycline being used.[2] Erythromycin or azithromycin is recommended in babies and during pregnancy.[2] Sexual partners should also be treated and the infected people advised not to have sex for seven days and until symptom free.[2] Gonorrhea, syphilis, and HIV should be tested for in those who have been infected.[2] Following treatment people should be tested again after three months.[2]

Chlamydia is one of the most common sexually transmitted infections, affecting about 4.2% of women and 2.7% of men worldwide.[4][5] In 2015 about 61 million new cases occurred globally.[9] In the United States about 1.4 million cases were reported in 2014.[3] Infections are most common among those between the ages of 15 and 25 and are more common in women than men.[2][3] In 2015 infections resulted in about 200 deaths.[6] The word chlamydia is from the Greek χλαμύδα, meaning "cloak".[10][11]

Signs and symptoms

Genital disease

Inflammation of the cervix from chlamydia infection characterized by mucopurulent cervical discharge, redness, and inflammation
A white, cloudy or watery discharge may emerge from the tip of the penis.

Women

Chlamydial infection of the cervix (neck of the womb) is a sexually transmitted infection which has no symptoms for 50–70% of women infected. The infection can be passed through vaginal, anal, or oral sex. Of those who have an asymptomatic infection that is not detected by their doctor, approximately half will develop pelvic inflammatory disease (PID), a generic term for infection of the uterus, fallopian tubes, and/or ovaries. PID can cause scarring inside the reproductive organs, which can later cause serious complications, including chronic pelvic pain, difficulty becoming pregnant, ectopic (tubal) pregnancy, and other dangerous complications of pregnancy.[citation needed]

Chlamydia is known as the "silent epidemic", as in women it may not cause any symptoms in 70–80% of cases,[12] and can linger for months or years before being discovered. Signs and symptoms may include abnormal vaginal bleeding or discharge, abdominal pain, painful sexual intercourse, fever, painful urination or the urge to urinate more often than usual (urinary urgency).[citation needed]

For sexually active women who are not pregnant, screening is recommended in those under 25 and others at risk of infection.[13] Risk factors include a history of chlamydial or other sexually transmitted infection, new or multiple sexual partners, and inconsistent condom use.[14] Guidelines recommend all women attending for emergency contraceptive are offered Chlamydia testing, with studies showing up to 9% of women aged <25 years had Chlamydia.[15]

Men

In men, those with a chlamydial infection show symptoms of infectious inflammation of the urethra in about 50% of cases.[12] Symptoms that may occur include: a painful or burning sensation when urinating, an unusual discharge from the penis, testicular pain or swelling, or fever. If left untreated, chlamydia in men can spread to the testicles causing epididymitis, which in rare cases can lead to sterility if not treated.[12] Chlamydia is also a potential cause of prostatic inflammation in men, although the exact relevance in prostatitis is difficult to ascertain due to possible contamination from urethritis.[16]

Eye disease

Main article: Trachoma
Conjunctivitis due to chlamydia

Trachoma is a chronic conjunctivitis caused by Chlamydia trachomatis.[17] It was once the most important cause of blindness worldwide, but its role diminished from 15% of blindness cases by trachoma in 1995 to 3.6% in 2002.[18][19] The infection can be spread from eye to eye by fingers, shared towels or cloths, coughing and sneezing and eye-seeking flies.[20] Symptoms include mucopurulent ocular discharge, irritation, redness, and lid swelling.[17] Newborns can also develop chlamydia eye infection through childbirth (see below). Using the SAFE strategy (acronym for surgery for in-growing or in-turned lashes, antibiotics, facial cleanliness, and environmental improvements), the World Health Organization aims for the global elimination of trachoma by 2020 (GET 2020 initiative).[21][22]

Joints

Chlamydia may also cause reactive arthritis—the triad of arthritis, conjunctivitis and urethral inflammation—especially in young men. About 15,000 men develop reactive arthritis due to chlamydia infection each year in the U.S., and about 5,000 are permanently affected by it. It can occur in both sexes, though is more common in men.[citation needed]

Infants

As many as half of all infants born to mothers with chlamydia will be born with the disease. Chlamydia can affect infants by causing spontaneous abortion; premature birth; conjunctivitis, which may lead to blindness; and pneumonia.[23] Conjunctivitis due to chlamydia typically occurs one week after birth (compared with chemical causes (within hours) or gonorrhea (2–5 days)).

Other conditions

A different serovar of Chlamydia trachomatis is also the cause of lymphogranuloma venereum, an infection of the lymph nodes and lymphatics. It usually presents with genital ulceration and swollen lymph nodes in the groin, but it may also manifest as rectal inflammation, fever or swollen lymph nodes in other regions of the body.[24]

Transmission

Chlamydia can be transmitted during vaginal, anal, or oral sex or direct contact with infected tissue such as conjunctiva. Chlamydia can also be passed from an infected mother to her baby during vaginal childbirth.[23]

Pathophysiology

Chlamydiae have the ability to establish long-term associations with host cells. When an infected host cell is starved for various nutrients such as amino acids (for example, tryptophan),[25] iron, or vitamins, this has a negative consequence for Chlamydiae since the organism is dependent on the host cell for these nutrients. Long-term cohort studies indicate that approximately 50% of those infected clear within a year, 80% within two years, and 90% within three years.[26]

The starved chlamydiae enter a persistent growth state wherein they stop cell division and become morphologically aberrant by increasing in size.[27] Persistent organisms remain viable as they are capable of returning to a normal growth state once conditions in the host cell improve.

There is debate as to whether persistence has relevance. Some believe that persistent chlamydiae are the cause of chronic chlamydial diseases. Some antibiotics such as β-lactams have been found to induce a persistent-like growth state.[28][29]

Diagnosis

Chlamydia trachomatis inclusion bodies (brown) in a McCoy cell culture

The diagnosis of genital chlamydial infections evolved rapidly from the 1990s through 2006. Nucleic acid amplification tests (NAAT), such as polymerase chain reaction (PCR), transcription mediated amplification (TMA), and the DNA strand displacement amplification (SDA) now are the mainstays. NAAT for chlamydia may be performed on swab specimens sampled from the cervix (women) or urethra (men), on self-collected vaginal swabs, or on voided urine.[30] NAAT has been estimated to have a sensitivity of approximately 90% and a specificity of approximately 99%, regardless of sampling from a cervical swab or by urine specimen.[31] In women seeking an STI clinic and a urine test is negative, a subsequent cervical swab has been estimated to be positive in approximately 2% of the time.[31]

At present, the NAATs have regulatory approval only for testing urogenital specimens, although rapidly evolving research indicates that they may give reliable results on rectal specimens.

Because of improved test accuracy, ease of specimen management, convenience in specimen management, and ease of screening sexually active men and women, the NAATs have largely replaced culture, the historic gold standard for chlamydia diagnosis, and the non-amplified probe tests. The latter test is relatively insensitive, successfully detecting only 60–80% of infections in asymptomatic women, and often giving falsely-positive results. Culture remains useful in selected circumstances and is currently the only assay approved for testing non-genital specimens. Other method also exist including: ligase chain reaction (LCR), direct fluorescent antibody resting, enzyme immunoassay, and cell culture.[32]

Rapid point-of-care tests are, as of 2020, not thought to be effective for diagnosing chlamydia in men of reproductive age and nonpregnant women because of a high false-negative rates.[33]

Prevention

Prevention is by not having sex, the use of condoms, or having sex with only partners, who are not infected.[1]

Screening

For sexually active women who are not pregnant, screening is recommended in those under 25 and others at risk of infection.[13] Risk factors include a history of chlamydial or other sexually transmitted infection, new or multiple sexual partners, and inconsistent condom use.[14] For pregnant women, guidelines vary: screening women with age or other risk factors is recommended by the U.S. Preventive Services Task Force (USPSTF) (which recommends screening women under 25) and the American Academy of Family Physicians (which recommends screening women aged 25 or younger). The American College of Obstetricians and Gynecologists recommends screening all at risk, while the Centers for Disease Control and Prevention recommend universal screening of pregnant women.[13] The USPSTF acknowledges that in some communities there may be other risk factors for infection, such as ethnicity.[13] Evidence-based recommendations for screening initiation, intervals and termination are currently not possible.[13] For men, the USPSTF concludes evidence is currently insufficient to determine if regular screening of men for chlamydia is beneficial.[14] They recommend regular screening of men who are at increased risk for HIV or syphilis infection.[14] A Cochrane review found that the effects of screening are uncertain in terms of chlamydia transmission but that screening probably reduces the risk of pelvic inflammatory disease in women.[34]

In the United Kingdom the National Health Service (NHS) aims to:

  1. Prevent and control chlamydia infection through early detection and treatment of asymptomatic infection;
  2. Reduce onward transmission to sexual partners;
  3. Prevent the consequences of untreated infection;
  4. Test at least 25 percent of the sexually active under 25 population annually.[35]
  5. Retest after treatment.[36]

Treatment

C. trachomatis infection can be effectively cured with antibiotics. Guidelines recommend azithromycin, doxycycline, erythromycin, levofloxacin or ofloxacin.[37] In men, doxycycline (100 mg twice a day for 7 days) is probably more effective than azithromycin (1 g single dose) but evidence for the relative effectiveness of antibiotics in women is very uncertain.[38] Agents recommended during pregnancy include erythromycin or amoxicillin.[2][39]

An option for treating sexual partners of those with chlamydia or gonorrhea includes patient-delivered partner therapy (PDT or PDPT), which is the practice of treating the sex partners of index cases by providing prescriptions or medications to the patient to take to his/her partner without the health care provider first examining the partner.[40]

Following treatment people should be tested again after three months to check for reinfection.[2]

Epidemiology

Disability-adjusted life year (DALY) for chlamydia per 100,000 inhabitants in 2004[41]
  no data
  ≤10
  10–20
  20–30
  30–40
  40–50
  50–60
  60–70
  70–80
  80–90
  90–100
  100–110
  more than 110

Globally, as of 2015, sexually transmitted chlamydia affects approximately 61 million people.[9] It is more common in women (3.8%) than men (2.5%).[42] In 2015 it resulted in about 200 deaths.[6]

In the United States about 1.6 million cases were reported in 2016.[43] The CDC estimates that if one includes unreported cases there are about 2.9 million each year.[43] It affects around 2% of young people.[44] Chlamydial infection is the most common bacterial sexually transmitted infection in the UK.[45]

Chlamydia causes more than 250,000 cases of epididymitis in the U.S. each year. Chlamydia causes 250,000 to 500,000 cases of PID every year in the United States. Women infected with chlamydia are up to five times more likely to become infected with HIV, if exposed.[23]

References

  1. ^ a b c d e f g h i j k l "Chlamydia – CDC Fact Sheet". CDC. May 19, 2016. Archived from the original on 11 June 2016. Retrieved 10 June 2016.
  2. ^ a b c d e f g h i j k l m n o "2015 Sexually Transmitted Diseases Treatment Guidelines". CDC. June 4, 2015. Archived from the original on 11 June 2016. Retrieved 10 June 2016.
  3. ^ a b c d "2014 Sexually Transmitted Diseases Surveillance Chlamydia". November 17, 2015. Archived from the original on 10 June 2016. Retrieved 10 June 2016.
  4. ^ a b Newman, Lori; Rowley, Jane; Vander Hoorn, Stephen; Wijesooriya, Nalinka Saman; Unemo, Magnus; Low, Nicola; Stevens, Gretchen; Gottlieb, Sami; Kiarie, James; Temmerman, Marleen; Meng, Zhefeng (8 December 2015). "Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting". PLOS ONE. 10 (12): e0143304. Bibcode:2015PLoSO..1043304N. doi:10.1371/journal.pone.0143304. PMC 4672879. PMID 26646541.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  5. ^ a b "Sexually transmitted infections (STIs) Fact sheet N°110". who.int. December 2015. Archived from the original on 25 November 2014. Retrieved 10 June 2016.
  6. ^ a b c GBD 2015 Mortality and Causes of Death, Collaborators. (8 October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281. {{cite journal}}: |first1= has generic name (help)CS1 maint: numeric names: authors list (link)
  7. ^ a b "CDC – Trachoma, Hygiene-related Diseases, Healthy Water". Centers for Disease Control and Prevention. December 28, 2009. Archived from the original on September 5, 2015. Retrieved 2015-07-24.
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  9. ^ a b GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282. {{cite journal}}: |first1= has generic name (help)CS1 maint: numeric names: authors list (link)
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  22. ^ Ngondi J, Onsarigo A, Matthews F, Reacher M, Brayne C, Baba S, Solomon AW, Zingeser J, Emerson PM (2006). "Effect of 3 years of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) strategy for trachoma control in southern Sudan: a cross-sectional study". Lancet. 368 (9535): 589–95. doi:10.1016/S0140-6736(06)69202-7. PMID 16905023. S2CID 45018412.
  23. ^ a b c "STD Facts – Chlamydia". Center For Disease Control. December 16, 2014. Archived from the original on July 14, 2015. Retrieved 2015-07-24.
  24. ^ Williams D, Churchill D (2006). "Ulcerative proctitis in men who have sex with men: an emerging outbreak". BMJ. 332 (7533): 99–100. doi:10.1136/bmj.332.7533.99. PMC 1326936. PMID 16410585.
  25. ^ Leonhardt RM, Lee SJ, Kavathas PB, Cresswell P (2007). "Severe Tryptophan Starvation Blocks Onset of Conventional Persistence and Reduces Reactivation of Chlamydia trachomatis". Infect. Immun. 75 (11): 5105–17. doi:10.1128/IAI.00668-07. PMC 2168275. PMID 17724071.
  26. ^ Fairley CK, Gurrin L, Walker J, Hocking JS (2007). ""Doctor, How Long Has My Chlamydia Been There?" Answer:"... Years"". Sexually Transmitted Diseases. 34 (9): 727–8. doi:10.1097/OLQ.0b013e31812dfb6e. PMID 17717486.
  27. ^ Mpiga P, Ravaoarinoro M (2006). "Chlamydia trachomatis persistence: an update". Microbiol. Res. 161 (1): 9–19. doi:10.1016/j.micres.2005.04.004. PMID 16338585.
  28. ^ Bayramova, Firuza; Jacquier, Nicolas; Greub, Gilbert (2018). "Insight in the biology of Chlamydia-related bacteria". Microbes and Infection. 20 (7–8). Elsevier: 432–440. doi:10.1016/j.micinf.2017.11.008. PMID 29269129.
  29. ^ Klöckner, Anna; Bühl, Henrike; Viollier, Patrick; Henrichfreise, Beate (2018). "Deconstructing the Chlamydial Cell Wall". In Häcker, Georg (ed.). Biology of Chlamydia. Current Topics in Microbiology and Immunology. Vol. 412. Cham: Springer International Publishing. pp. 1–33. doi:10.1007/82_2016_34. ISBN 978-3-319-71232-1. PMID 27726004. {{cite book}}: Unknown parameter |booktitle= ignored (help)
  30. ^ Gaydos CA; et al. (2004). "Comparison of three nucleic acid amplification tests for detection of Chlamydia trachomatis in urine specimens". J Clin Microbiol. 42 (7): 3041–3045. CiteSeerX 10.1.1.335.7713. doi:10.1128/JCM.42.7.3041-3045.2004. PMC 446239. PMID 15243057.
  31. ^ a b Haugland S, Thune T, Fosse B, Wentzel-Larsen T, Hjelmevoll SO, Myrmel H (2010). "Comparing urine samples and cervical swabs for Chlamydia testing in a female population by means of Strand Displacement Assay (SDA)". BMC Women's Health. 10 (1): 9. doi:10.1186/1472-6874-10-9. PMC 2861009. PMID 20338058.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  32. ^ "Recommendations for the Laboratory-Based Detection of Chlamydia trachomatis and Neisseria gonorrhoeae — 2014". www.cdc.gov. Archived from the original on 2016-06-27. Retrieved 2016-06-12.
  33. ^ Grillo-Ardila, CF; Torres, M; Gaitán, HG (29 January 2020). "Rapid point of care test for detecting urogenital Chlamydia trachomatis infection in nonpregnant women and men at reproductive age". The Cochrane Database of Systematic Reviews. 1: CD011708. doi:10.1002/14651858.CD011708.pub2. PMC 6988850. PMID 31995238.
  34. ^ Low, N; Redmond, S; Uusküla, A; van Bergen, J; Ward, H; Andersen, B; Götz, H (13 September 2016). "Screening for genital chlamydia infection". The Cochrane Database of Systematic Reviews. 9: CD010866. doi:10.1002/14651858.CD010866.pub2. PMC 6457643. PMID 27623210.
  35. ^ "National Chlamydia Screening Programme Data tables". www.chlamydiascreening.nhs.uk. Archived from the original on 2009-05-04. Retrieved 2009-08-28.
  36. ^ Desai, Monica; Woodhall, Sarah C; Nardone, Anthony; Burns, Fiona; Mercey, Danielle; Gilson, Richard (2015). "Active recall to increase HIV and STI testing: a systematic review". Sexually Transmitted Infections. 91 (5): sextrans–2014–051930. doi:10.1136/sextrans-2014-051930. ISSN 1368-4973. PMID 25759476Strategies for improved follow up care include the use of text messages and emails from those who provided treatment.{{cite journal}}: CS1 maint: postscript (link)
  37. ^ Eliopoulos GM, Gilbert DN, Moellering RC, eds. (2015). The Sanford guide to antimicrobial therapy 2011. Sperryville, VA: Antimicrobial Therapy, Inc. pp. 20. ISBN 978-1-930808-65-2.
  38. ^ Páez-Canro, C; Alzate, JP; González, LM; Rubio-Romero, JA; Lethaby, A; Gaitán, HG (25 January 2019). "Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non-pregnant women". The Cochrane Database of Systematic Reviews. 1: CD010871. doi:10.1002/14651858.CD010871.pub2. PMC 6353232. PMID 30682211.
  39. ^ Miller, Karl E. (2006-04-15). "Diagnosis and Treatment of Chlamydia trachomatis Infection". American Family Physician. 73 (8): 1411–1416. PMID 16669564. Archived from the original on November 27, 2011. Retrieved 2010-10-30.
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