Vecuronium bromide
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| Routes of administration | IV |
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| Elimination half-life | 51-80 minutes |
| Excretion | Feces (40-75%); urine (30% as unchanged drug and metabolites) |
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| ECHA InfoCard | 100.051.549 |
Vecuronium bromide is a muscle relaxant in the category of non depolarising neuromuscular blocking agents. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Clinical Pharmacology
Vecuronium operates by competing for the cholinergic receptors at the motor end plate thereby exerting its muscle relaxing properties which are used adjunctively to general anesthesia. Under balanced anesthesia, the time to recovery to 25% of control (clinical duration) is approximately 25 to 40 minutes after injection and recovery is usually 95% complete approximately 45 to 65 minutes after injection of intubating dose. The neuromuscular blocking action of vecuronium is slightly enhanced in the presence of potent inhalation anesthetics. If vecuronium is first administered more than 5 minutes after the start of the inhalation of enflurane, isoflurane, or halothane, or when steady state has been achieved, the intubating dose of vecuronium may be decreased by approximately 15%.
Vecuronium is normally given at 0.08-0.1mg/kg intravenously and its maintenance dose is usually between 0.02-0.03mg/kg, but as with all other neuromuscular blocking agents, the doses need to be tailored for each individual patient.
Uses in Popular Culture
- Vecuronium is used in an episode of the television show House M.D. to paralyze a patient with uncontrollable muscle spasms.
- Vecuronium is also used by terrorists in the video game Metal Gear Acid to sedate all of the passengers on a airplane, thus becoming hostages.
- Dr. Luka Kovac is forcibly administered vecuronium by two prisoners in a botched attempt to escape from police custody in hospital in an episode of ER titled "21 Guns."
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- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.