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This is an old revision of this page, as edited by 95.76.2.123 (talk) at 15:56, 10 September 2020 (→What the fuck is with this paragraph?: new section). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Mechanism of action

"Methandrostenolone does not react strongly with the androgen receptor, instead relying on activity not mediated by the receptor for its effects."

Results reported in:
"Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: a comparative study" by B. I. Feldkoren and S. Andersson in J Steroid Biochem Mol Biol. (2005) volume 94 pages 481-487. PMID 15876413
seem to suggest that even if methandrostenolone does not have a high affinity for the androgen receptor, it can still have effects of the androgen receptor. --JWSchmidt 14:00, 11 October 2005 (UTC)[reply]

You are correct, even though it has lower binding affinity for the androgen receptor, the reference says that it is still acting through the androgen receptor in vivo. This article is littered with pseduoscience and unsupported statements. --Settersr (talk) —Preceding undated comment was added at 19:44, 11 October 2008 (UTC).[reply]

Too right, it sucks. --90.240.69.136 (talk) 19:51, 11 October 2008 (UTC)[reply]
Reads like a dodgy advert to me. Testem (talk) 19:17, 15 March 2014 (UTC)[reply]

Metabolism

"The 17α-methylation of the steroid does allow it to pass through the liver without being broken down (hence causing the aforementioned damage to the liver) allowing it to be taken orally"

This sentence is mixing together two ideas. The structure of methandrostenolone makes it less rapidly converted to inactive forms than are some other androgens. However, this does not mean that it is not broken down by the liver. The sentence in the article implies that it it because methandrostenolone is not broken down by the liver that it damages the liver. This is very unlikely. Many of the key articles on this chemical were published in German. Maybe someone who can read German and who has access to a research library can sort this out.--JWSchmidt 21:47, 11 October 2005 (UTC)[reply]


Just curious, how has it been established 30mg per day is a "high dose"?

Answer: It doesn't sound high to me, but a check of an old PDR would determine the answer to your question. —Preceding unsigned comment added by Godofredo29 (talk • contribs) 19:04, 19 November 2007 (UTC)[reply]

Allusions to Sports Figures

The link to Bob Hoffman is not to the right Bob Hoffman. —Preceding unsigned comment added by Godofredo29 (talk • contribs) 19:01, 19 November 2007 (UTC)[reply]

The origin of methandrostenolone

Hi, I am confused by the information contained in the World Anabolic Review that methandrostenolone "was developed in the mid-forties and experimentally used on returning prisoners of war that had been on very low food intakes." Other sources say that it was synthesized as late as in mid 50's in USA. What is true? Centrum99 (talk) 21:56, 20 July 2008 (UTC)[reply]

Side effects and death due to liver dysfunction

Dianabol (methandrostenolone) is not directly responsible for that. Any medicine (steroidal or not) can cause death, because every medicine is hepatotoxic. Liver shut down appears only when using fancy dosages (in the case of Dianabol : over 50 mg a day) while not protecting the liver with Liv52 (for instance).

Professional (and amateur) bodybuilders do use it at 25-50 mg a day and do not suffer from liver dysfunction or disturbing side effects.

Maybe should it be useful to detail a bit more the cases when the use could lead to death. If it was so dangerous, no one would be taking steroids.

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What the fuck is with this paragraph?

What kind of mouthbreathing mongoloid wrote this and thought it was ok? And why is it still here and hasn't been deleted yet?

It is very common to use an oral steroid at the beginning of a cycle depending on if it's 10 weeks 16 weeks. Because when injecting testosterone and other compounds January text up to the third week to fully saturate your body and feel the effects. People they call it a jump start in the beginning will use dbol or Anadrol oh, various other ones that's a jump-start because they feel orals quickly within a day or two. Most squirrels can be liver toxic but not as greatly as the media or society would lead you to believe. Can this girls with Anadrol, Winstrol, anavar I can go on. But personally I did it just to check it out for an experiment I did 2 blood test and my first blood test specifically just had two days of Motrin so essentially for Motrin used in this 2 days. And then I waited a week to get the other one just so nothing was affecting my enzymes except I was using Anadrol-50. Out of the shoe study that I did myself the study of the two days taking for Motrin Greeley I'll beat the steady pace of oral steroids for 2 weeks. Also by further researching you can actually crush up these oral steroids very pop into a fine powder. And put them under your tongue or between your cheek and let it dissolve no different than somebody would with a nitroglycerin pill or a subutex. And then from there your capillaries absorb it in your mouth. I'm not sitting here trying to justify using steroids and that they are safe and that is all dose-dependent anyway and or if you have pre-existing medical issues.

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