While significantly more powerful than the .25-20 Winchester, the .25-35 WCF can be used to hunt small deer at 200 yards and medium-sized deer at 100 yards, though some consider it better suited to small predators such as coyotes instead. It was a popular round used in the Winchester Model 1885 High Wall single-shot rifle. No production rifles had been made in .25-35 WCF since the 1940s until 2005 when Winchester resumed chambering their Model 94 rifles in this cartridge. Winchester ammunition has kept the cartridge in production in the U.S.A.
The 6.5x52R is a European cartridge that is a close variant of the .25-35 Winchester. It should not be considered identical to the .25-35 Winchester and is not treated as such by the Commission Internationale Permanente pour l'Epreuve des Armes à Feu Portatives (CIP), which has released separate specifications for each cartridge. The 6.5x52R has its origins in Germany and was introduced by RWS and is chambered in many drilling and single-shot rifles. Any interchangeability between the two cartridges is solely dependent on individual chamber tolerances and should not be assumed.