2-Hydroxymuconate-6-semialdehyde dehydrogenase

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2-Hydroxymuconate-6-semialdehyde dehydrogenase
EC number1.2.1.85
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

2-Hydroxymuconate-6-semialdehyde dehydrogenase (EC, xylG (gene), praB (gene)) is an enzyme with systematic name (2E,4Z)-2-hydroxy-6-oxohexa-2,4-dienoate:NAD+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

2-hydroxymuconate-6-semialdehyde + NAD+ + H2O (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+

This substrate for this enzyme is formed by meta ring cleavage of catechol (EC, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds.


  1. ^ Inoue J, Shaw JP, Rekik M, Harayama S (March 1995). "Overlapping substrate specificities of benzaldehyde dehydrogenase (the xylC gene product) and 2-hydroxymuconic semialdehyde dehydrogenase (the xylG gene product) encoded by TOL plasmid pWW0 of Pseudomonas putida". Journal of Bacteriology. 177 (5): 1196–201. PMC 176723. PMID 7868591.
  2. ^ Orii C, Takenaka S, Murakami S, Aoki K (November 2006). "Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: A different modified meta-cleavage pathway for 2-aminophenols". Bioscience, Biotechnology, and Biochemistry. 70 (11): 2653–61. doi:10.1271/bbb.60264. PMID 17090920.
  3. ^ Kasai D, Fujinami T, Abe T, Mase K, Katayama Y, Fukuda M, Masai E (November 2009). "Uncovering the protocatechuate 2,3-cleavage pathway genes". Journal of Bacteriology. 191 (21): 6758–68. doi:10.1128/JB.00840-09. PMC 2795304. PMID 19717587.

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