2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase
| 2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.201 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase (EC 2.1.1.201, ubiE (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol 5-C-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol
This enzyme is involved in ubiquinone biosynthesis.
References
- ^ Lee, P.T.; Hsu, A.Y.; Ha, H.T.; Clarke, C.F. (1997). "A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene". J. Bacteriol. 179 (5): 1748–1754. PMC 178890. PMID 9045837.
- ^ Young, I.G.; McCann, L.M.; Stroobant, P.; Gibson, F. (1971). "Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone". J. Bacteriol. 105 (3): 769–778. PMID 4323297.
- ^ Dibrov, E.; Robinson, K.M.; Lemire, B.D. (1997). "The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain". J. Biol. Chem. 272 (14): 9175–9181. doi:10.1074/jbc.272.14.9175. PMID 9083048.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Barkovich, R.J.; Shtanko, A.; Shepherd, J.A.; Lee, P.T.; Myles, D.C.; Tzagoloff, A.; Clarke, C.F. (1997). "Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis". J. Biol. Chem. 272 (14): 9182–9188. doi:10.1074/jbc.272.14.9182. PMID 9083049.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
External links
- 2-methoxy-6-polyprenyl-1,4-benzoquinol+methylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)