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2-dehydropantoate aldolase

From Wikipedia, the free encyclopedia
2-dehydropantoate aldolase
Identifiers
EC no.4.1.2.12
CAS no.9024-51-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

The enzyme 2-dehydropantoate aldolase (EC 4.1.2.12) catalyzes the chemical reaction:

2-dehydropantoate 3-methyl-2-oxobutanoate + formaldehyde

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include ketopantoaldolase, and 2-dehydropantoate formaldehyde-lyase.

References

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  • McIntosh EN, Purko M, Wood WA (1957). "Ketopantoate formation by a hydroxymethylation enzyme from Escherichia coli". J. Biol. Chem. 228 (1): 499–510. PMID 13475336.