2-oxoglutarate decarboxylase

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2-oxoglutarate decarboxylase
2xt9.jpg
2-oxoglutarate decarboxylase heterotetramer, Mycobacterium smegmatis
Identifiers
EC number4.1.1.71
CAS number37205-42-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 2-oxoglutarate decarboxylase (EC 4.1.1.71) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate succinate semialdehyde + CO2

Hence, this enzyme has one substrate, 2-oxoglutarate, and two products, succinate semialdehyde and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming). Other names in common use include oxoglutarate decarboxylase, alpha-ketoglutarate decarboxylase, alpha-ketoglutaric decarboxylase, oxoglutarate decarboxylase, pre-2-oxoglutarate decarboxylase, and 2-oxoglutarate carboxy-lyase. It employs one cofactor, thiamin diphosphate.

References[edit]

  • Shigeoka S, Onishi T, Maeda K, Nakano Y, Kitaoka S (1986). "Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate decarboxylase in mitochondria of Euglena gracilis". FEBS Lett. 195: 43–47. doi:10.1016/0014-5793(86)80126-0.