The 2006 National Lacrosse League season was the 20th season in the history of the league, which began as the Eagle Pro Box Lacrosse League in 1987. The season began on December 30, 2005 and concluded with the championship game on May 13, 2006.
The defending champion Toronto Rock were once again the favourite to win the Champions' Cup, but a slow start plus a dismal performance in the semifinal game against Rochester removed the Rock from contention. The Colorado Mammoth, under first-year head coach Gary Gait, won their first title since winning the first ever title in 1987, as the Baltimore Thunder.
The season featured the debut of two expansion teams; the Edmonton Rush and the Portland LumberJax, both in the Western Division. Portland beat the expansion team odds and won its division, finishing with an 11–5 record, while Edmonton did not fare so well. The Rush finished the season 1–15, their only win coming at the hands of their provincial rivals, the Calgary Roughnecks.
Before the 2006 season, the Anaheim Storm folded not being able to attract enough fans in their two years in Southern California moving from their original home of New Jersey after the 2003 season where, for two seasons, they were not able to attract enough fans.
x–Clinched playoff berth; c–Clinched playoff berth by crossing over to another division; y–Clinched division; z–Clinched best regular season record; GP–Games Played; W–Wins; L–Losses GB–Games back; PCT–Win percentage; Home–Record at Home; Road–Record on the Road; GF–Goals scored; GA–Goals allowed; Diff–Difference between goals scored and allowed Toronto won the 3-way tiebreaker with Minnesota and Philadelphia
The 2006 All-Star Game was held at the Air Canada Centre in Toronto, Ontario on February 25, 2006. The West Division defeated the East Division 14–13. The MVP of the game was Lewis Ratcliff of the Calgary Roughnecks, who scored 4 goals, including the game winner. This marked the second straight year that a Roughneck player was All-Star Game MVP, with Tracy Kelusky having won it in 2005.