23S rRNA (adenine2503-C2,C8)-dimethyltransferase
| 23S rRNA (adenine2503-C2,C8)-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.194 | ||||||||
| CAS no. | 39369-30-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA (adenine2503-C2,C8)-dimethyltransferase (EC 2.1.1.194, Cfr, Cfr methyltransferase, Cfr rRNA methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine2503-C2,C8)-dimethyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA 2 S-adenosyl-L-homocysteine + 2,8-dimethyladenine2503 in 23S rRNA
This enzyme contains an [4Fe-S] cluster.
References
- ^ Yan, F.; LaMarre, J.M.; Röhrich, R.; Wiesner, J.; Jomaa, H.; Mankin, A.S.; Fujimori, D.G. (2010). "RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA". J. Am. Chem. Soc. 132 (11): 3953–3964. doi:10.1021/ja910850y. PMC 2859901. PMID 20184321.
- ^ Giessing, A.M.; Jensen, S.S.; Rasmussen, A.; Hansen, L.H.; Gondela, A.; Long, K.; Vester, B.; Kirpekar, F. (2009). "Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria". RNA. 15 (2): 327–336. doi:10.1261/rna.1371409. PMC 2648713. PMID 19144912.
- ^ Kaminska, K.H.; Purta, E.; Hansen, L.H.; Bujnicki, J.M.; Vester, B.; Long, K.S. (2010). "Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria". Nucleic Acids Res. 38 (5): 1652–1663. doi:10.1093/nar/gkp1142. PMC 2836569. PMID 20007606.
External links
- 23S+rRNA+(adenine2503-C2,C8)-dimethyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)