3-dehydro-L-gulonate-6-phosphate decarboxylase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
3-dehydro-L-gulonate-6-phosphate decarboxylase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a 3-dehydro-L-gulonate-6-phosphate decarboxylase (EC is an enzyme that catalyzes the chemical reaction

3-dehydro-L-gulonate 6-phosphate + H+ L-xylulose 5-phosphate + CO2

Thus, the two substrates of this enzyme are 3-dehydro-L-gulonate 6-phosphate and H+, whereas its two products are L-xylulose 5-phosphate and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming). Other names in common use include 3-keto-L-gulonate 6-phosphate decarboxylase, UlaD, SgaH, SgbH, KGPDC, and 3-dehydro-L-gulonate-6-phosphate carboxy-lyase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.


  • Yew WS, Gerlt JA (January 2002). "Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons". Journal of Bacteriology. 184 (1): 302–6. doi:10.1128/JB.184.1.302-306.2002. PMC 134747. PMID 11741871.
  • Wise E, Yew WS, Babbitt PC, Gerlt JA, Rayment I (March 2002). "Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase". Biochemistry. 41 (12): 3861–9. doi:10.1021/bi012174e. PMID 11900527.