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3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase

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3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
Identifiers
EC no.4.1.1.51
CAS no.37289-49-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

The enzyme 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase (EC 4.1.1.51) catalyzes the chemical reaction

3-hydroxy-2-methylpyridine-4,5-dicarboxylate 3-hydroxy-2-methylpyridine-5-carboxylate + CO2

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming). This enzyme is also called 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase. This enzyme participates in vitamin B6 metabolism.

References

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  • Snell EE, Smucker AA, Ringelmann E, Lynen F (1964). "Die bakterielle Oxydation des Vitamin B6. IV. Die enzymatische Decarboxylierung von 2-Methyl-3-hydroxypyridine-4,5-dicarbonsaure". Biochem. Z. 341: 109–119.