3-mercaptopyruvate sulfurtransferase
| 3-mercaptopyruvate sulfurtransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.1.2 | ||||||||
| CAS no. | 9026-05-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2) is an enzyme that catalyzes the chemical reaction
- 3-mercaptopyruvate + cyanide pyruvate + thiocyanate
- 3-mercaptopyruvate + thiol pyruvate + hydrogen sulfide
This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3-mercaptopyruvate:cyanide sulfurtransferase. This enzyme is also called beta-mercaptopyruvate sulfurtransferase. This enzyme participates in cysteine metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1OKG and 1URH.
References
- Fiedler H; Wood JL (1956). "Specificity studies on the beta-mercaptopyruvate-cyanide transsulfuration system". J. Biol. Chem. 222 (1): 387–397. PMID 13367011.
- HYLIN JW; WOOD JL (1959). "Enzymatic formation of polysulfides from mercaptopyruvate". J. Biol. Chem. 234 (8): 2141–4. PMID 13673028.
- Sorbo BH (1957). "Enzymic transfer of sulfur from mercaptopyruvate to sulfite or sulfinates". Biochem. Biophys. Acta. 24: 324–329. doi:10.1016/0006-3002(57)90201-9.
- Vachek H; Wood JL (1972). "Purification and properties of mercaptopyruvate sulfur transferase of Escherichia coli". Biochim. Biophys. Acta. 258 (1): 133–46. doi:10.1016/0005-2744(72)90973-4. PMID 4550801.
- Van den Hamer CJ; Morell AG; Scheinberg IH (1967). "A study of the cooper content of beta-mercaptopyruvate trans-sulfurase". J. Biol. Chem. 242 (10): 2514–6. PMID 6026243.