8-hydroxyfuranocoumarin 8-O-methyltransferase
| 8-hydroxyfuranocoumarin 8-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.70 | ||||||||
| CAS no. | 67339-13-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
8-hydroxyfuranocoumarin 8-O-methyltransferase (EC 2.1.1.70, furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, xanthotoxol 8-O-methyltransferase, XMT, SAM:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase, xanthotoxol methyltransferase, xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine-xanthotoxol O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction)
- (2) S-adenosyl-L-methionine + xanthotoxol S-adenosyl-L-homocysteine + xanthotoxin
8-hydroxyfuranocoumarin 8-O-methyltransferase converts xanthotoxol into xanthotoxin.
References
- ^ Thompson, H.J., Sharma, S.K. and Brown, S.A. (1978). "O-Methyltransferases of furanocoumarin biosynthesis". Arch. Biochem. Biophys. 188: 272–281. doi:10.1016/s0003-9861(78)80009-5. PMID 28084.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Hauffe, K.D., Hahlbrock, K. and Scheel, D. (1986). "Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases". Z. Naturforsch. C. 41: 228–239.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Sharma, S.K., Garrett, J.M. and Brown, S.A. (1979). "Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography". Z. Naturforsch. C. 34C: 387–391. PMID 156999.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Hehmann, M., Lukačin, R., Ekiert, H. and Matern, U. (2004). "Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase". Eur. J. Biochem. 271: 932–940. doi:10.1111/j.1432-1033.2004.03995.x. PMID 15009205.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
External links
- 8-hydroxyfuranocoumarin+8-O-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)