From Wikipedia, the free encyclopedia
Clusterin associated protein 1 , also known as CLUAP1, is a human gene .[ 5]
Model organisms
Model organisms have been used in the study of CLUAP1 function. A conditional knockout mouse line, called Cluap1tm1a(KOMP)Wtsi [ 11] [ 12] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[ 13] [ 14] [ 15]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[ 9] [ 16] mutant mice and four significant abnormalities were observed.[ 9] homozygous mutant embryos were identified during gestation, and therefore none survived until weaning . The remaining tests were carried out on heterozygous mutant adult mice; both sexes had decreased IgG1 levels while males also displayed abnormal spine curvature resulting in kyphosis .[ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000103351 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014232 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: clusterin associated protein 1" . Retrieved 2011-08-30 .^ "Radiography data for Cluap1" . Wellcome Trust Sanger Institute.^ "Salmonella infection data for Cluap1" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Cluap1" . Wellcome Trust Sanger Institute.^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Mouse Resources Portal , Wellcome Trust Sanger Institute.^ "International Knockout Mouse Consortium" . Archived from the original on 2012-05-29. Retrieved 2012-02-14 .^ "Mouse Genome Informatics" .^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . S2CID 39281705 . ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 . PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biol . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 . {{cite journal }}: CS1 maint: unflagged free DOI (link )
External links
Further reading
Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Follit JA, Xu F, Keady BT, Pazour GJ (2009). "Characterization of mouse IFT complex B" . Cell Motility and the Cytoskeleton . 66 (8): 457–68. doi :10.1002/cm.20346 . PMC 2753169 PMID 19253336 . Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Research . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nature Genetics . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . S2CID 21903526 . Strausberg RL, Feingold EA, Grouse LH (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proceedings of the National Academy of Sciences USA . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Ishikawa K, Nagase T, Suyama M (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Research . 5 (3): 169–76. doi :10.1093/dnares/5.3.169 PMID 9734811 . Takahashi M, Lin YM, Nakamura Y, Furukawa Y (2004). "Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer" . Oncogene . 23 (57): 9289–94. doi :10.1038/sj.onc.1208100 PMID 15480429 . S2CID 20970407 . Ishikura H, Ikeda H, Abe H (2007). "Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system". International Journal of Oncology . 30 (2): 461–7. doi :10.3892/ijo.30.2.461 (inactive 2021-01-14). PMID 17203229 . {{cite journal }}: CS1 maint: DOI inactive as of January 2021 (link )
