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Protein-coding gene in the species Homo sapiens
Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene .[ 5] [ 6] [ 7]
MAP1A and MAP1B are microtubule -associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton . MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B.[ 7]
MAPLC3A is one of the mammalian homologues of yeast ATG8 , an important marker and effector of autophagy .[ 8]
MAP1LC3A is regulated by several post-translational modifications . These include covalent linkage of the C-terminus to phosphatidylethanolamine in autophagic membranes, and phosphorylation by protein kinase A ,[ 9] interact with sequestosome 1 .[ 10]
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