Revision as of 03:49, 28 October 2022 by Ffffrr(talk | contribs)(Importing Wikidata short description: "Protein-coding gene in the species Homo sapiens")
SPARC-like protein 1 (SPARCL1 or SC1), also known as hevin (short for high endothelial venule protein), is a secreted protein with high structural similarity to SPARC.[5][6] It interacts with the extracellular matrix to create intermediate states of cell adhesion.[7] Due to its dynamic extracellular roles, being implicated in cancer metastasis and inflammation, it is considered a matricellular protein.[8][9] In humans hevin is encoded by the SPARCL1gene.[10][11]
^Sullivan MM, Sage EH (June 2004). "Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family". The International Journal of Biochemistry & Cell Biology. 36 (6): 991–6. doi:10.1016/j.biocel.2004.01.017. PMID15094114.
^Schraml P, Shipman R, Stulz P, Ludwig CU (March 1993). "cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST)". Trends in Genetics. 9 (3): 70–1. doi:10.1016/0168-9525(93)90216-5. PMID8488563.
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, et al. (June 2004). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology. 22 (6): 724–31. doi:10.1038/nbt969. PMID15146195. S2CID36630738.
Li Y, Aroca-Aguilar JD, Ghosh S, Sánchez-Sánchez F, Escribano J, Coca-Prados M (January 2006). "Interaction of myocilin with the C-terminal region of hevin". Biochemical and Biophysical Research Communications. 339 (3): 797–804. doi:10.1016/j.bbrc.2005.11.082. PMID16316624.
Scalabrini D, Fenoglio C, Scarpini E, De Riz M, Comi C, Venturelli E, et al. (October 2007). "Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis". Neuroscience Letters. 425 (3): 173–6. doi:10.1016/j.neulet.2007.08.020. PMID17825989. S2CID9381979.